Schiffrin A D, Desrosiers M, Aleyassine H, Belmonte M M
Diabetes Care. 1984 Mar-Apr;7(2):107-13. doi: 10.2337/diacare.7.2.107.
The effects of continuous subcutaneous insulin infusion (CSII), intensified conventional therapy (ICT), and a combination of CSII and ICT (CSII-ICT) on metabolic control were compared in a group of twenty type I diabetic adolescents who had previously failed to respond to twice-daily injections and home glucose monitoring. A marked improvement in control was observed when mean glycemia and glycosylated hemoglobin A1 (HbA1) were compared with conventional therapy (CT). In the course of CSII, a lower HbA1 (P less than 0.05) and mean capillary blood glucose (CBG) (P less than 0.04) were observed than during ICT and CSII-ICT. Acceptability of CSII was greater than that of ICT and CSII-ICT, with 50% of the patients opting for this therapy at the end of the 1-yr trial. The marked improvement of control observed under CSII for the group as a whole was maintained after 6 mo of completion of the study. Thus, it appears that in type I diabetic adolescents CSII is more effective and acceptable than ICT and CSII-ICT.
在一组20名I型糖尿病青少年中，比较了持续皮下胰岛素输注（CSII）、强化常规治疗（ICT）以及CSII与ICT联合治疗（CSII-ICT）对代谢控制的影响。这些青少年此前对每日两次注射胰岛素及家庭血糖监测治疗均无反应。将平均血糖水平和糖化血红蛋白A1（HbA1）与常规治疗（CT）进行比较时，观察到治疗控制情况有显著改善。在CSII治疗过程中，与ICT及CSII-ICT治疗期间相比，观察到HbA1水平更低（P<0.05），平均毛细血管血糖（CBG）水平也更低（P<0.04）。CSII的可接受性高于ICT及CSII-ICT，在为期1年的试验结束时，50%的患者选择了这种治疗方法。在研究完成6个月后，整个组在CSII治疗下观察到的显著控制改善情况得以维持。因此，对于I型糖尿病青少年而言，CSII似乎比ICT及CSII-ICT更有效且更易接受。
