Witt M F, White N H, Santiago J V
J Pediatr. 1983 Oct;103(4):528-33. doi: 10.1016/s0022-3476(83)80577-0.
To investigate the effect of site and timing of insulin injection on post-breakfast plasma glucose concentration, 23 children with type 1 diabetes were given their usual mixture of short- and intermediate-acting insulin five minutes prior to breakfast on one day and between 15 and 60 minutes before breakfast on the alternate day, depending on their 7:00 AM fasting blood glucose concentration. Thirteen children received insulin in an extremity, and 10 in the abdominal wall. Plasma insulin and glucose patterns were similar for the two injection sites. The mean post-breakfast peak glucose increment was significantly lower and the mean increment in free insulin values during the first hour after breakfast was higher on the day when insulin preceded breakfast by 30 to 60 minutes. Thus, significant reductions in post-breakfast hyperglycemia can be achieved by increasing the interval between the injection and breakfast in proportion to the fasting capillary glucose concentration. The timing of the morning insulin injection may be more important than the injection site.
为研究胰岛素注射部位和时间对早餐后血浆葡萄糖浓度的影响，23名1型糖尿病患儿在一天早餐前5分钟注射其常用的短效和中效胰岛素混合剂，在另一天则根据其上午7:00的空腹血糖浓度在早餐前15至60分钟注射。13名儿童在四肢注射胰岛素，10名在腹壁注射。两个注射部位的血浆胰岛素和葡萄糖模式相似。在胰岛素在早餐前30至60分钟注射的那天，早餐后平均血糖峰值增量显著更低，早餐后第一小时内游离胰岛素值的平均增量更高。因此，通过根据空腹毛细血管血糖浓度按比例增加注射与早餐之间的间隔时间，可以显著降低早餐后高血糖。早晨胰岛素注射的时间可能比注射部位更重要。
