Sackey A H, Jefferson I G
Hull and East Yorkshire Children's Diabetes Clinic, Hull Royal Infirmary.
Arch Dis Child. 1994 Sep;71(3):248-50. doi: 10.1136/adc.71.3.248.
The relationship between the insulin-breakfast interval, postprandial increase in blood glucose, and glycaemic control was studied in 58 children with diabetes. Patients recorded insulin-breakfast intervals in a home diary over a seven day period, and during a 24 hour period at the weekend provided eight serial capillary dried blood spots for glucose analysis. The highest mean blood glucose value occurred two hours after breakfast and showed a significant correlation with fructosamine concentrations. Weekend insulin-breakfast intervals ranged from 2-30 minutes, with 70% reporting intervals of less than 15 minutes. There was a significant correlation between the weekend insulin-breakfast interval and the after breakfast increase in blood glucose with a mean increment of 0.4 mmol/l in the 30 minute group and 7.2 mmol/l in the 2 minute group. Over the whole study period, children with mean insulin-breakfast intervals of two to 12 minutes had a mean fructosamine concentration of 376 mumol/l compared with 341 mumol/l in those with intervals of 15-35 minutes. This study has shown that the interval between insulin injection and breakfast significantly influences the morning postprandial rise in blood glucose and consequently short term glycaemic control. It is therefore important that patients are encouraged to leave an interval of about 30 minutes between insulin injection and breakfast.
对58名糖尿病儿童的胰岛素注射与早餐间隔时间、餐后血糖升高及血糖控制之间的关系进行了研究。患者在家庭日记中记录了7天的胰岛素注射与早餐间隔时间，并在周末的24小时内提供了8个连续的毛细血管干血斑用于血糖分析。早餐后两小时血糖值最高，且与果糖胺浓度显著相关。周末胰岛素注射与早餐间隔时间为2 - 30分钟，70%的患者报告间隔时间少于15分钟。周末胰岛素注射与早餐间隔时间和早餐后血糖升高之间存在显著相关性，30分钟组血糖平均升高0.4 mmol/l，2分钟组为7.2 mmol/l。在整个研究期间，胰岛素注射与早餐间隔时间平均为2至12分钟的儿童，果糖胺平均浓度为376 μmol/l，而间隔时间为15至35分钟的儿童为341 μmol/l。该研究表明，胰岛素注射与早餐之间的间隔时间显著影响早餐后血糖的升高，进而影响短期血糖控制。因此，鼓励患者在胰岛素注射与早餐之间留出约30分钟的间隔时间很重要。
