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阴道内应用白细胞干扰素凝胶治疗宫颈上皮内瘤变（CIN）。

Intravaginal application of leukocyte interferon gel in the treatment of cervical intraepithelial neoplasia (CIN).

作者信息

Choo Y C, Hsu C, Seto W H, Miller D G, Merigan T C, Ng M H, Ma H K

出版信息

Arch Gynecol. 1985;237(1):51-4. doi: 10.1007/BF02133952.

DOI:10.1007/BF02133952
PMID:4051584
Abstract

Leukocyte interferon gel (1 X 10(6) units) was applied twice daily by a vaginal applicator to areas of cervical intraepithelial neoplasia (CIN) in 7 patients. A partial response was obtained in 3 patients and complete response in 2 patients. This suggests that leukocyte interferon gel can be used to treat CIN.

摘要

用阴道给药器将白细胞干扰素凝胶（1×10⁶单位）每日两次涂抹于7例宫颈上皮内瘤变（CIN）患者的病变部位。3例患者有部分反应，2例患者有完全反应。这表明白细胞干扰素凝胶可用于治疗CIN。

相似文献

1
Intravaginal application of leukocyte interferon gel in the treatment of cervical intraepithelial neoplasia (CIN).阴道内应用白细胞干扰素凝胶治疗宫颈上皮内瘤变（CIN）。
Arch Gynecol. 1985;237(1):51-4. doi: 10.1007/BF02133952.
2
Cytokine serum levels in patients with cervical intraepithelial neoplasia grade II-III treated with intralesional interferon-α 2b.病灶内注射α-2b干扰素治疗的II-III级宫颈上皮内瘤变患者的细胞因子血清水平
Tumori. 2011 Sep-Oct;97(5):578-84. doi: 10.1177/030089161109700507.
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Treatment of dysplasia of the cervical epithelium with an interferon gel.用干扰素凝胶治疗宫颈上皮发育异常。
Obstet Gynecol. 1983 Nov;62(5):625-9.
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Vaginal 5-fluorouracil for high-grade cervical dysplasia in human immunodeficiency virus infection: a randomized trial.阴道用5-氟尿嘧啶治疗人类免疫缺陷病毒感染中的高级别宫颈发育异常：一项随机试验。
Obstet Gynecol. 1999 Dec;94(6):954-61. doi: 10.1016/s0029-7844(99)00407-x.
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[Clinical studies on intravaginal administration of CDDP for dysplasia, carcinoma in situ and microinvasive carcinoma of the uterine cervix].顺铂经阴道给药治疗子宫颈发育异常、原位癌及微浸润癌的临床研究
Nihon Sanka Fujinka Gakkai Zasshi. 1992 Feb;44(2):208-14.
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Natural cytotoxicity in malignant and premalignant cervical neoplasia and enhancement of cytotoxicity with interferon.恶性及癌前宫颈肿瘤中的自然细胞毒性以及干扰素对细胞毒性的增强作用。
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An evaluation of immune system cell infiltrate in the cervical stroma of patients with grade III cervical intraepithelial neoplasia after treatment with intralesional alpha-2B interferon.对经病灶内注射α-2B干扰素治疗的III级宫颈上皮内瘤变患者宫颈基质中免疫系统细胞浸润情况的评估。
Eur J Gynaecol Oncol. 2014;35(1):20-5.
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Topical 5-fluorouracil treatment of transformation zone intraepithelial neoplasia of cervix and vagina.局部应用5-氟尿嘧啶治疗宫颈和阴道转化区上皮内瘤变。
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Cervical intraepithelial neoplasia treated by perilesional injection of interferon.通过病灶周围注射干扰素治疗宫颈上皮内瘤变。
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Preliminary stop of the TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia (TOPIC) trial.咪喹莫特局部治疗高级别宫颈上皮内瘤变（TOPIC）试验的初步中止
BMC Cancer. 2017 Feb 7;17(1):110. doi: 10.1186/s12885-017-3108-9.

引用本文的文献

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Topical therapies for the treatment of cervical intraepithelial neoplasia (CIN) 2-3: A narrative review.用于治疗宫颈上皮内瘤变（CIN）2-3级的局部治疗：一篇叙述性综述。
Gynecol Oncol Rep. 2020 Jul 2;33:100608. doi: 10.1016/j.gore.2020.100608. eCollection 2020 Aug.
2
Efficacy trial of topically administered interferon gamma-1 beta gel in comparison to laser treatment in cervical intraepithelial neoplasia.局部应用干扰素γ-1β凝胶与激光治疗宫颈上皮内瘤变的疗效试验
Arch Gynecol Obstet. 1995;256(2):75-83. doi: 10.1007/BF00634712.

本文引用的文献

1
Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells.悬浮L细胞中病毒干扰的定量研究。III. 干扰病毒和干扰素对细胞生长速率的影响。
Virology. 1962 Jun;17:324-34. doi: 10.1016/0042-6822(62)90123-x.
2
Treatment of dysplasia of the cervical epithelium with an interferon gel.用干扰素凝胶治疗宫颈上皮发育异常。
Obstet Gynecol. 1983 Nov;62(5):625-9.
3
Human papillomavirus lesions in association with cervical dysplasias and neoplasias.与宫颈发育异常和肿瘤形成相关的人乳头瘤病毒病变
Obstet Gynecol. 1983 Nov;62(5):617-24.
4
Interferon treatment of uterine cervical precancerosis.子宫颈癌前病变的干扰素治疗。
J Cancer Res Clin Oncol. 1981;101(3):303-8. doi: 10.1007/BF00410115.