Pride G L, Chuprevich T W
Obstet Gynecol. 1982 Oct;60(4):467-72.
The authors present preliminary findings in 11 unselected patients with upper vaginal and/or cervical transformation zone intraepithelial neoplasia treated with a 5% topical 5-fluorouracil (5-FU) cream. Only 6 of 11 patients were found to be cured of disease when subsequently evaluated histologically by conization biopsy and/or hysterectomy. Although further clinical trials using differing concentrations and/or more prolonged exposure to the drug may be warranted, the authors cannot recommend topical 5-FU as a replacement for standard outpatient therapy for upper vaginal and/or cervical intraepithelial neoplasia.
作者报告了11例未经选择的患有阴道上段和/或宫颈转化区上皮内瘤变的患者，使用5%外用5-氟尿嘧啶（5-FU）乳膏治疗的初步结果。在随后通过锥形活检和/或子宫切除术进行组织学评估时，11例患者中只有6例被发现疾病治愈。尽管可能有必要进行使用不同浓度和/或更长时间接触该药物的进一步临床试验，但作者不推荐将外用5-FU作为阴道上段和/或宫颈上皮内瘤变标准门诊治疗的替代方法。
