局部用阿昔洛韦治疗生殖器疱疹：与全身治疗的比较。

Topical acyclovir in the treatment of genital herpes: a comparison with systemic therapy.

作者信息

Fiddian A P, Kinghorn G R, Goldmeier D, Rees E, Rodin P, Thin R N, de Konig G A

出版信息

J Antimicrob Chemother. 1983 Sep;12 Suppl B:67-77. doi: 10.1093/jac/12.suppl_b.67.

DOI:10.1093/jac/12.suppl_b.67

Abstract

Controlled trials of acyclovir cream were conducted in the treatment of initial and recurrent genital herpes. For 54 patients with the first episode of genital infection (initial disease) treated with acyclovir the duration of viral shedding, formation of new lesions, times to crusting and healing and duration of symptoms were significantly reduced compared with the results obtained in 47 placebo recipients. When applied early in the course of recurrent episodes in 44 patients, acyclovir cream significantly reduced viral shedding, a new lesion formation, time to healing and the duration of symptoms compared with the effects in 41 control patients. Topical therapy with acyclovir cream is well tolerated and compares quite favourably with systemic treatment, especially for recurrent genital herpes.

摘要

进行了阿昔洛韦乳膏治疗初发性和复发性生殖器疱疹的对照试验。在54例接受阿昔洛韦治疗的生殖器感染首发患者（初发性疾病）中，与47例接受安慰剂治疗的患者相比，病毒排出持续时间、新病灶形成、结痂和愈合时间以及症状持续时间均显著缩短。在44例复发性发作患者病程早期应用阿昔洛韦乳膏时，与41例对照患者相比，阿昔洛韦乳膏显著减少了病毒排出、新病灶形成、愈合时间和症状持续时间。阿昔洛韦乳膏局部治疗耐受性良好，与全身治疗相比相当有利，尤其是对于复发性生殖器疱疹。