阿昔洛韦乳膏治疗复发性唇疱疹失败。
Failure of acyclovir cream in treatment of recurrent herpes labialis.
作者信息
Shaw M, King M, Best J M, Banatvala J E, Gibson J R, Klaber M R
出版信息
Br Med J (Clin Res Ed). 1985 Jul 6;291(6487):7-9. doi: 10.1136/bmj.291.6487.7.
Abstract
A double blind, randomised, crossover placebo controlled trial of 5% acyclovir cream, applied topically five times a day for five days, was carried out in 45 patients with recurrent herpes labialis. These patients had a total of 72 episodes, 34 of which were treated with the 5% acyclovir cream and 38 with placebo cream. Treatment was begun by the patients as soon as possible after the onset of prodromal symptoms. There was no significant clinical benefit from treatment with acyclovir cream compared with placebo cream. The median healing times were nine days with acyclovir cream, 10 days with placebo cream, and 13 days when no treatment was given. The possibility that the 40% propylene glycol cream base alone has a therapeutic effect must therefore be considered.
摘要
对45例复发性唇疱疹患者进行了一项双盲、随机、交叉安慰剂对照试验，使用5%阿昔洛韦乳膏，每天局部涂抹5次，共5天。这些患者共有72次发作，其中34次用5%阿昔洛韦乳膏治疗，38次用安慰剂乳膏治疗。患者在前驱症状出现后尽快开始治疗。与安慰剂乳膏相比，阿昔洛韦乳膏治疗无显著临床益处。使用阿昔洛韦乳膏的中位愈合时间为9天，使用安慰剂乳膏为10天，未治疗时为13天。因此，必须考虑仅40%丙二醇乳膏基质本身具有治疗作用的可能性。
相似文献
1
Failure of acyclovir cream in treatment of recurrent herpes labialis.阿昔洛韦乳膏治疗复发性唇疱疹失败。
Br Med J (Clin Res Ed). 1985 Jul 6;291(6487):7-9. doi: 10.1136/bmj.291.6487.7.
2
Successful treatment of herpes labialis with topical acyclovir.外用阿昔洛韦成功治疗唇疱疹。
Br Med J (Clin Res Ed). 1983 May 28;286(6379):1699-701. doi: 10.1136/bmj.286.6379.1699.
3
Acyclovir in the management of herpes labialis.阿昔洛韦用于唇疱疹的治疗。
J Antimicrob Chemother. 1983 Sep;12 Suppl B:95-103. doi: 10.1093/jac/12.suppl_b.95.
4
Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections.复发性口面部单纯疱疹感染患者的局部阿昔洛韦治疗
J Antimicrob Chemother. 1983 Sep;12 Suppl B:89-93. doi: 10.1093/jac/12.suppl_b.89.
5
6
Treatment of herpes labialis with acyclovir. Review of three clinical trials.阿昔洛韦治疗唇疱疹。三项临床试验综述。
Am J Med. 1988 Aug 29;85(2A):39-42.
7
Topical acyclovir in the management of recurrent herpes labialis.外用阿昔洛韦治疗复发性唇疱疹
Br J Dermatol. 1983 Sep;109(3):321-6. doi: 10.1111/j.1365-2133.1983.tb03548.x.
8
Herpes labialis treatment with acyclovir 5 per cent ointment.用5%阿昔洛韦软膏治疗唇疱疹。
J Can Dent Assoc. 1989 Feb;55(2):135-7.
9
Double-blind, randomized, placebo-controlled study of topical 5% acyclovir-1% hydrocortisone cream (ME-609) for treatment of UV radiation-induced herpes labialis.5%阿昔洛韦-1%氢化可的松乳膏（ME-609）局部用药治疗紫外线辐射引起的唇疱疹的双盲、随机、安慰剂对照研究。
Antimicrob Agents Chemother. 2002 Jun;46(6):1870-4. doi: 10.1128/AAC.46.6.1870-1874.2002.
10
Topical acyclovir in the treatment of recurrent herpes simplex virus infections.局部用阿昔洛韦治疗复发性单纯疱疹病毒感染
Scand J Infect Dis Suppl. 1985;47:58-62.
引用本文的文献
1
Instantaneous Inactivation of Herpes Simplex Virus by Silicon Nitride Bioceramics.硅氮化物生物陶瓷对单纯疱疹病毒的瞬间灭活作用。
Int J Mol Sci. 2023 Aug 10;24(16):12657. doi: 10.3390/ijms241612657.
2
Herpes labialis.唇疱疹
BMJ Clin Evid. 2009 Sep 23;2009:1704.
3
Treatment and prevention of herpes labialis.唇疱疹的治疗与预防。
Can Fam Physician. 2008 Dec;54(12):1683-7.
4
Acyclovir cream for treatment of herpes simplex labialis: results of two randomized, double-blind, vehicle-controlled, multicenter clinical trials.阿昔洛韦乳膏治疗唇疱疹：两项随机、双盲、赋形剂对照、多中心临床试验结果
Antimicrob Agents Chemother. 2002 Jul;46(7):2238-43. doi: 10.1128/AAC.46.7.2238-2243.2002.
5
Sodium lauryl sulfate increases the efficacy of a topical formulation of foscarnet against herpes simplex virus type 1 cutaneous lesions in mice.十二烷基硫酸钠可提高膦甲酸钠局部制剂对小鼠1型单纯疱疹病毒皮肤损伤的疗效。
Antimicrob Agents Chemother. 2000 Sep;44(9):2263-70. doi: 10.1128/AAC.44.9.2263-2270.2000.
6
A risk-benefit evaluation of aciclovir for the treatment and prophylaxis of herpes simplex virus infections.阿昔洛韦治疗和预防单纯疱疹病毒感染的风险效益评估。
Drug Saf. 2000 Aug;23(2):131-42. doi: 10.2165/00002018-200023020-00004.
7
Effect of foscarnet cream on experimental UV radiation-induced herpes labialis.膦甲酸钠乳膏对实验性紫外线诱导唇疱疹的作用。
Antimicrob Agents Chemother. 1997 Sep;41(9):1961-4. doi: 10.1128/AAC.41.9.1961.
8
Chemotherapy of herpesvirus infections: present successes and future hopes.
Eur J Clin Microbiol. 1985 Oct;4(5):459-63. doi: 10.1007/BF02014424.
9
Topical treatment of recurrent genital herpes simplex virus infections with trisodium phosphonoformate (foscarnet): double blind, placebo controlled, multicentre study.膦甲酸钠三钠（膦甲酸）局部治疗复发性生殖器单纯疱疹病毒感染：双盲、安慰剂对照、多中心研究。
Genitourin Med. 1986 Aug;62(4):247-50. doi: 10.1136/sti.62.4.247.
10
Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy.阿昔洛韦。对其抗病毒活性、药代动力学特性及治疗效果的最新综述。
Drugs. 1989 Mar;37(3):233-309. doi: 10.2165/00003495-198937030-00002.
本文引用的文献
1
Herpes virus in an obstetric hospital: I: Herpetic eruptions.
Med J Aust. 1980 Aug 23;2(4):205-8.
2
Efficacy of topical acyclovir cream in first and recurrent episodes of genital herpes.
Antiviral Res. 1983 Dec;3(5-6):291-301. doi: 10.1016/0166-3542(83)90037-2.
3
Successful treatment of herpes labialis with topical acyclovir.外用阿昔洛韦成功治疗唇疱疹。
Br Med J (Clin Res Ed). 1983 May 28;286(6379):1699-701. doi: 10.1136/bmj.286.6379.1699.
4
Acyclovir in the management of herpes labialis.阿昔洛韦用于唇疱疹的治疗。
J Antimicrob Chemother. 1983 Sep;12 Suppl B:95-103. doi: 10.1093/jac/12.suppl_b.95.
5
Topical acyclovir therapy in patients with recurrent orofacial herpes simplex infections.复发性口面部单纯疱疹感染患者的局部阿昔洛韦治疗
J Antimicrob Chemother. 1983 Sep;12 Suppl B:89-93. doi: 10.1093/jac/12.suppl_b.89.
6
Topical acyclovir in the treatment of genital herpes: a comparison with systemic therapy.局部用阿昔洛韦治疗生殖器疱疹：与全身治疗的比较。
J Antimicrob Chemother. 1983 Sep;12 Suppl B:67-77. doi: 10.1093/jac/12.suppl_b.67.
7
Topical acyclovir in the management of recurrent herpes labialis.外用阿昔洛韦治疗复发性唇疱疹
Br J Dermatol. 1983 Sep;109(3):321-6. doi: 10.1111/j.1365-2133.1983.tb03548.x.
8
Treatment of herpes labialis.唇疱疹的治疗。
J Infect. 1983 May;6(1 Suppl):41-7. doi: 10.1016/s0163-4453(83)94118-x.
9
Sensitivity of herpes virus isolates from acyclovir clinical trials.来自阿昔洛韦临床试验的疱疹病毒分离株的敏感性。
Am J Med. 1982 Jul 20;73(1A):380-2. doi: 10.1016/0002-9343(82)90127-9.
10
A collaborative study of patient-initiated treatment of recurrent genital herpes with topical acyclovir or placebo.一项关于复发性生殖器疱疹患者自行使用局部阿昔洛韦或安慰剂治疗的合作研究。
J Infect Dis. 1984 Jul;150(1):1-6. doi: 10.1093/infdis/150.1.1.
Zotero 插件