Ernst J D, Rusnak M, Sande M A
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S626-30. doi: 10.1093/clinids/5.supplement_3.s626.
Disseminated candidiasis was established in guinea pigs immunosuppressed with high-dose cortisone acetate. After the disease had been characterized by histopathologic study and quantitative culture of selected organs, guinea pigs were given amphotericin B alone or in combination with rifampin. The addition of rifampin to the regimen enhanced the in vitro rate of killing of the strain of Candida albicans used in the studies but was not noticeably beneficial in treatment of the disease in guinea pigs. Thus, the demonstration of an enhanced rate of killing in vitro was not a reliable basis for prediction of the response to the drug in vivo.
用高剂量醋酸可的松免疫抑制的豚鼠建立了播散性念珠菌病。在用组织病理学研究和选定器官的定量培养对疾病进行表征后，给豚鼠单独使用两性霉素B或与利福平联合使用。在治疗方案中加入利福平提高了研究中所用白色念珠菌菌株的体外杀灭率，但在豚鼠疾病治疗中并没有明显益处。因此，体外杀灭率提高的证明并不是预测药物体内反应的可靠依据。
