人白细胞干扰素对HEp-2细胞培养物中沙门氏菌属侵袭性的影响。
Effect of human leukocyte interferon on invasiveness of Salmonella species in HEp-2 cell cultures.
作者信息
Bukholm G, Degré M
出版信息
Infect Immun. 1983 Dec;42(3):1198-202. doi: 10.1128/iai.42.3.1198-1202.1983.
Abstract
The effect of human leukocyte interferon on the invasiveness of Salmonella and Shigella species in HEp-2 cell cultures was examined. The intracellular and extracellular bacteria were identified by a combination of Nomarski differential interference contrast microscopy and UV incident light microscopy applied on the same microscope. Pretreatment of HEp-2 cells with human leukocyte interferon reduced the number of Salmonella typhimurium and Salmonella paratyphi-B bacteria per cell and the proportion of cells containing bacteria in a dose-dependent manner. Maximum inhibitory effect was observed with ca. 100 U of interferon per ml. The inhibitory effect was neutralized with anti-human interferon globulin. Murine fibroblast interferon did not influence the invasiveness of Salmonella species. Invasiveness of Shigella flexneri was not influenced by treatment of cells with human interferon.
摘要
研究了人白细胞干扰素对HEp - 2细胞培养物中沙门氏菌和志贺氏菌侵袭性的影响。通过在同一显微镜上应用Nomarski微分干涉对比显微镜和紫外线入射光显微镜相结合的方法来鉴定细胞内和细胞外的细菌。用人白细胞干扰素预处理HEp - 2细胞，以剂量依赖的方式减少了每个细胞中鼠伤寒沙门氏菌和副伤寒沙门氏菌B型细菌的数量以及含有细菌的细胞比例。每毫升约100 U干扰素时观察到最大抑制作用。该抑制作用被抗人干扰素球蛋白中和。鼠成纤维细胞干扰素不影响沙门氏菌的侵袭性。用人类干扰素处理细胞对福氏志贺氏菌的侵袭性没有影响。
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