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天然产物的药理学评价——民族药物筛选的一般方法和特定方法

The pharmacological evaluation of natural products--general and specific approaches to screening ethnopharmaceuticals.

作者信息

Malone M H

出版信息

J Ethnopharmacol. 1983 Aug;8(2):127-47. doi: 10.1016/0378-8741(83)90050-8.

DOI:10.1016/0378-8741(83)90050-8
PMID:6358706
Abstract

Natural product research is most efficiently conducted in a systematic fashion concentrating on ten critical questions which must be answered in sequential fashion by thoroughly trained professionals experienced in such research. The minimum ethnopharmacology research team should consist of a botanist, a chemist and a pharmacologist with each carrying the responsibility for answering certain of the critical questions. The screening procedures used for the evaluation of synthetic medicinals generally are not appropriate for guiding the extraction of active principles from crude drugs and establishing extraction efficiency; therefore, specialized techniques unique to ethnopharmacology must be used.

摘要

天然产物研究最有效的开展方式是系统地聚焦十个关键问题,这些问题必须由在此类研究方面经验丰富且训练有素的专业人员依次解答。最低限度的民族药理学研究团队应包括一名植物学家、一名化学家以及一名药理学家,他们各自负责回答某些关键问题。用于评估合成药物的筛选程序通常不适用于指导从天然药物中提取活性成分并确定提取效率;因此,必须采用民族药理学特有的专门技术。

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