Grafl H J, Schwantes H O
Z Ernahrungswiss. 1983 Sep;22(3):205-12. doi: 10.1007/BF02024695.
The difference between cadmium, zinc, lead, and mercury in regard of their effects on the activity of the enzymes tested is very slight. Concentrations higher than 10(-5) M reduce significantly the activity of the enzymes, and concentrations of approximately 10(-3) M inhibit it completely. An increase of the activity cannot be detected. The addition of combinations of cadmium, zinc, and lead results in a summing up of the toxic effects, whereas the interaction between mercury and the other three heavy metals shows a cumulative effect, which is appointed nearly completely by the heavy metal more toxic. The findings suggest that under in-vitro conditions there exists a direct interaction between the heavy metals and the enzymes.
镉、锌、铅和汞对所测试酶活性的影响差异非常小。浓度高于10⁻⁵ M会显著降低酶的活性，而浓度约为10⁻³ M时会完全抑制酶活性。未检测到酶活性增加。镉、锌和铅组合添加会导致毒性作用的累加，而汞与其他三种重金属之间的相互作用表现出累积效应，这种效应几乎完全由毒性更强的重金属决定。这些发现表明，在体外条件下，重金属与酶之间存在直接相互作用。
