实验性肺炎克雷伯菌烧伤创面败血症：荚膜多糖的作用
Experimental Klebsiella pneumoniae burn wound sepsis: role of capsular polysaccharide.
作者信息
Cryz S J, Fürer F, Germanier R
出版信息
Infect Immun. 1984 Jan;43(1):440-1. doi: 10.1128/iai.43.1.440-441.1984.
Abstract
The role of Klebsiella pneumoniae capsular polysaccharide in relation to virulence in a murine burn wound sepsis model was investigated. Burn trauma markedly predisposed mice to lethal K. pneumoniae sepsis. A highly encapsulated variant (KP1-O) derived from K. pneumoniae KP1 was found to be extremely virulent for burned mice (50% lethal dose less than 10 organisms), whereas another variant (KP1-T), which possessed a much smaller capsule, was comparatively nonvirulent (50% lethal dose greater than 10(6) organisms). Production of large quantities of capsular material by KP1-O allowed for its rapid growth in vivo and persistence in the blood and liver. These traits were not demonstrated by KP1-T, which was effectively cleared after challenge.
摘要
研究了肺炎克雷伯菌荚膜多糖在小鼠烧伤创面脓毒症模型中与毒力的关系。烧伤创伤使小鼠极易发生致死性肺炎克雷伯菌脓毒症。从肺炎克雷伯菌KP1衍生出的一个高度荚膜化变体（KP1-O）对烧伤小鼠具有极强的毒力（半数致死剂量小于10个菌），而另一个荚膜小得多的变体（KP1-T）则相对无毒（半数致死剂量大于10⁶个菌）。KP1-O产生大量荚膜物质，使其能在体内快速生长并在血液和肝脏中持续存在。KP1-T则未表现出这些特性，在攻击后被有效清除。
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