Holst J J, Schwartz T W, Lovgreen N A, Pedersen O, Beck-Nielsen H
Int J Obes. 1983;7(6):529-38.
The diurnal profiles of pancreatic glucagon, insulin, pancreatic polypeptide (PP), and enteroglucagon were studied in five obese non-diabetic subjects (195 +/- 11 per cent of ideal body weight) and in six age matched controls. All the subjects were served with ordinary mixed meals five times during the day. The obese subjects were normoglycemic but hyperinsulinemic. Both groups showed rapid increases in PP to all meals, but the PP-response was significantly impaired in the obese group during the first part of the day. Normal subjects showed significant enteroglucagon responses to all meals, and had elevated levels throughout the day. In obese subjects, levels and responses were much lower at all times. Pancreatic glucagon profiles were similar. It is concluded that the possible role of abnormalities of PP and enteroglucagon secretion in the pathogenesis of human obesity deserves further study.
在五名肥胖非糖尿病受试者（体重为理想体重的195±11%）和六名年龄匹配的对照者中，研究了胰高血糖素、胰岛素、胰多肽（PP）和肠高血糖素的昼夜变化情况。所有受试者在一天中进食五次普通混合餐。肥胖受试者血糖正常但胰岛素水平升高。两组对所有餐食的PP均迅速升高，但肥胖组在一天的第一时段PP反应明显受损。正常受试者对所有餐食均有明显的肠高血糖素反应，且全天水平升高。肥胖受试者在所有时间的水平和反应均低得多。胰高血糖素的变化情况相似。结论是，PP和肠高血糖素分泌异常在人类肥胖发病机制中的可能作用值得进一步研究。
