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原发性肾脏疾病及危险因素对肾移植存活的影响。

Effect of primary renal disease and risk factors on kidney graft survival.

作者信息

Keller F, Hasselmann J, Offermann G, Hantelmann W, Molzahn M, Rost A, Maiga M

出版信息

Int Urol Nephrol. 1983;15(3):281-8. doi: 10.1007/BF02083016.

DOI:10.1007/BF02083016
PMID:6360941
Abstract

The important role of immunological factors, HLA typing and pretransplant blood transfusion on improved kidney graft survival is well established. Additionally, graft survival depends on risk factors such as diabetes and age of the recipient. The effect of other clinical risk factors on graft survival was evaluated in 187 patients who received kidney transplants at our centre between 1970 and 1981. Graft survival according to the life table method and statistical analysis according to the logrank test revealed 4 main risk factors. Graft survival is significantly lower in type I diabetics and analgesic nephropathy, whereas it is better in hereditary and other renal diseases. Additional risk factors are coronary heart disease and repeated grafting. Time of dialysis before transplantation and age of the recipient showed no detrimental effect on graft survival.

摘要

免疫因素、人类白细胞抗原(HLA)分型及移植前输血对提高肾移植存活率的重要作用已得到充分证实。此外,移植肾的存活还取决于一些危险因素,如糖尿病和受者年龄。1970年至1981年间,我们中心对187例接受肾移植的患者评估了其他临床危险因素对移植肾存活的影响。根据寿命表法得出的移植肾存活率以及根据对数秩检验进行的统计分析揭示了4个主要危险因素。Ⅰ型糖尿病患者和镇痛剂肾病患者的移植肾存活率显著较低,而遗传性及其他肾脏疾病患者的移植肾存活率较高。另外的危险因素是冠心病和再次移植。移植前透析时间和受者年龄对移植肾存活无不利影响。

相似文献

1
Effect of primary renal disease and risk factors on kidney graft survival.原发性肾脏疾病及危险因素对肾移植存活的影响。
Int Urol Nephrol. 1983;15(3):281-8. doi: 10.1007/BF02083016.
2
Impact of diabetes mellitus on transplantation.糖尿病对移植的影响。
Clin Transpl. 2004:357-77.
3
Kidney transplantation in patients with type 1 diabetes mellitus: long-term prognosis for patients and grafts.1型糖尿病患者的肾移植:患者及移植物的长期预后
Korean J Intern Med. 2001 Jun;16(2):98-104. doi: 10.3904/kjim.2001.16.2.98.
4
Assessment of function and survival as measures of renal graft outcome following kidney and kidney-pancreas transplantation in type I diabetics.对I型糖尿病患者肾移植和肾-胰腺移植后肾移植结果的功能和存活情况评估。
Clin Transplant. 1998 Apr;12(2):93-8.
5
Kidney transplantation in type 2 diabetic patients: a comparison with matched non-diabetic subjects.2型糖尿病患者的肾移植:与匹配的非糖尿病受试者的比较。
Nephrol Dial Transplant. 2002 Sep;17(9):1678-83. doi: 10.1093/ndt/17.9.1678.
6
Cardiovascular morbidity and mortality in patients with diabetes mellitus type I after kidney transplantation: a case-control study.I型糖尿病患者肾移植后的心血管发病率和死亡率:一项病例对照研究。
Clin Nephrol. 2004 Apr;61(4):238-45. doi: 10.5414/cnp61238.
7
Long-term survival following kidney transplantation in 100 type I diabetic patients.100例I型糖尿病患者肾移植后的长期存活情况。
Transplantation. 1989 Jan;47(1):106-13. doi: 10.1097/00007890-198901000-00024.
8
Coronary artery disease in 100 diabetics with end-stage renal failure.100例终末期肾衰竭糖尿病患者的冠状动脉疾病
Transplant Proc. 1984 Jun;16(3):603-7.
9
Dominant effect of histocompatibility on ten-year kidney transplant survival.
Transplantation. 1988 Feb;45(2):410-5. doi: 10.1097/00007890-198802000-00033.
10
Pancreas graft survival in simultaneous pancreas-kidney versus pancreas-after-kidney and pancreas alone transplantations: a single institution experience.同期胰肾联合移植与肾移植后胰腺移植及单纯胰腺移植的胰腺移植物存活情况:单中心经验
Transplant Proc. 2013;45(10):3609-11. doi: 10.1016/j.transproceed.2013.10.019.

本文引用的文献

1
[Kidney transplantation. Indications, conditions and results].[肾移植。适应证、条件及结果]
Fortschr Med. 1982 Feb 11;100(6):203-8, 221.
2
Analysis of survival of end-stage renal disease patients.终末期肾病患者的生存分析。
Kidney Int. 1982 Jan;21(1):78-83. doi: 10.1038/ki.1982.11.
3
Predicting survival in adults with end-stage renal disease: an age equivalence index.预测终末期肾病成人患者的生存率:年龄等效指数
Ann Intern Med. 1982 Apr;96(4):417-23. doi: 10.7326/0003-4819-96-4-417.
4
Renal transplantation in patients over 50 years of age.50岁以上患者的肾移植
Transplant Proc. 1981 Mar;13(1 Pt 1):33-5.
5
Duration of first renal allograft survival as indicator of second allograft outcome.
Surgery. 1980 Oct;88(4):611-8.
6
Diabetic nephropathy: natural course, survivorship and therapy.糖尿病肾病:自然病程、生存率与治疗
Am J Nephrol. 1981;1(3-4):206-18. doi: 10.1159/000166541.
7
Blood transfusions and kidney transplantation.输血与肾移植。
Arch Intern Med. 1982 Apr;142(4):680-1.
8
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.需要对每位患者进行长期观察的随机临床试验的设计与分析。II. 分析与示例。
Br J Cancer. 1977 Jan;35(1):1-39. doi: 10.1038/bjc.1977.1.
9
Combined Report on Regular Dialysis and Transplantation in Europe, IX, 1978.
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10
High-risk patients in renal transplantation.肾移植中的高危患者。
Transplant Proc. 1977 Mar;9(1):107-11.