Duval-Iflah Y, Chappuis J P, Ducluzeau R, Raibaud P
Prog Food Nutr Sci. 1983;7(3-4):107-16.
A plasmid-free human Escherichia coli strain EMO, was inoculated to human newborns within two hours of life. It became established in the feces at a high population level. Ampicillin and tetracycline resistant E. coli strains disappeared or decreased to subdominant level in the inoculated newborns whereas they remained at a high level in the noninoculated newborns. Strain EMO was also shown to exert a barrier effect against a porcine plasmid-bearing enterotoxigenic Ent+ K88- E. coli strain in gnotobiotic mice. Axenic piglets monoassociated with Ent+ K88- E. coli strain died within 6 days. Axenic piglets diassociated with both EMO and the Ent+ E. coli survived longer, though no significant difference was observed between the population level of the Ent+ E. coli in the mono- and diassociated piglet feces. These results suggest that a prior inoculation with a non-pathogenic E. coli strain may improve the spontaneous ecological protection of piglets against Ent+ E. coli strains.
一种无质粒的人源大肠杆菌菌株EMO，在出生后两小时内接种给人类新生儿。它在粪便中以高种群水平定植。在接种的新生儿中，氨苄青霉素和四环素抗性大肠杆菌菌株消失或降至次要水平，而在未接种的新生儿中它们仍处于高水平。菌株EMO在无菌小鼠中也显示出对携带猪质粒的产肠毒素Ent+ K88-大肠杆菌菌株具有屏障作用。与Ent+ K88-大肠杆菌菌株单联的无菌仔猪在6天内死亡。与EMO和Ent+大肠杆菌双联的无菌仔猪存活时间更长，尽管在单联和双联仔猪粪便中Ent+大肠杆菌的种群水平之间未观察到显著差异。这些结果表明，预先接种非致病性大肠杆菌菌株可能会改善仔猪对Ent+大肠杆菌菌株的自发生态保护。
