Mills K C, Bisgrove E Z
Alcohol Clin Exp Res. 1983 Fall;7(4):393-7. doi: 10.1111/j.1530-0277.1983.tb05492.x.
This study assessed women and men on a divided attention task, body sway, and subjective (self-report) estimates of impairment across different doses of alcohol. Twelve females and 12 males (mean age of 20.4 years) were given placebo, low, and high doses of alcohol in random order across sessions. Each subject was tested 3 times during each session. The study controlled for recent drinking history by restricting participation to light drinkers who were matched on age and education. Alcohol doses were adjusted for body fat and equivalent blood alcohol concentrations (BACs) were attained in the two gender groups. The results indicated that women and men did not differ in their extent of cognitive impairment at placebo and low alcohol doses. However, women showed significantly more cognitive impairment than their male counterparts at the high alcohol doses, even with equivalent BACs. The sway measure was influenced only by BAC and not by the gender of the subject. Sway observations were less sensitive and more variable than estimates of cognitive impairment. The subjective impairment data indicated that female subjects were less sensitive than males to the effects of alcohol at both the low and high doses. Implications for future research on cognitive impairment are discussed.
本研究评估了男性和女性在不同酒精剂量下的注意力分散任务、身体摇摆以及主观（自我报告）的损伤估计情况。12名女性和12名男性（平均年龄20.4岁）在不同时段被随机给予安慰剂、低剂量酒精和高剂量酒精。每个受试者在每个时段接受3次测试。该研究通过将参与对象限制为年龄和教育程度匹配的轻度饮酒者来控制近期饮酒史。根据身体脂肪调整酒精剂量，使两个性别组达到等效的血液酒精浓度（BAC）。结果表明，在安慰剂和低酒精剂量下，男性和女性的认知损伤程度没有差异。然而，即使BAC相同，在高酒精剂量下，女性比男性表现出明显更多的认知损伤。摇摆测量仅受BAC影响，而不受受试者性别的影响。与认知损伤估计相比，摇摆观察不太敏感且变化更大。主观损伤数据表明，在低剂量和高剂量下，女性受试者对酒精作用的敏感性均低于男性。文中讨论了对未来认知损伤研究的启示。
