• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2-negative target cells.单克隆抗Lyt-2.2抗体可阻断H-2阴性靶细胞的凝集素依赖性细胞毒性。
J Exp Med. 1984 Feb 1;159(2):551-8. doi: 10.1084/jem.159.2.551.
2
Clonal analysis of cytolytic T lymphocyte-mediated lysis of target cells with inducible antigen expression: correlation between antigen density and requirement for Lyt-2/3 function.对具有诱导性抗原表达的靶细胞进行细胞溶解T淋巴细胞介导的裂解的克隆分析：抗原密度与Lyt-2/3功能需求之间的相关性。
J Immunol. 1985 Aug;135(2):892-9.
3
Blocking of CTL-mediated killing by monoclonal antibodies to LFA-1 and Lyt-2, 3. II. Evidence that trypsin pretreatment of target cells removes a non-H-2 molecule important in killing.用抗淋巴细胞功能相关抗原-1（LFA-1）和抗Lyt-2、3单克隆抗体阻断细胞毒性T淋巴细胞（CTL）介导的杀伤作用。II. 靶细胞经胰蛋白酶预处理可去除杀伤过程中起重要作用的非H-2分子的证据。
J Immunol. 1985 Jan;134(1):70-7.
4
Induction of cytolytic T lymphocytes by mitogenic lectins is specifically inhibited by anti-Lyt-2 antibodies.促有丝分裂凝集素诱导的细胞溶解性T淋巴细胞会被抗Lyt-2抗体特异性抑制。
Eur J Immunol. 1983 Jun;13(6):476-80. doi: 10.1002/eji.1830130609.
5
Cytolytic T lymphocyte clones that proliferate autonomously to specific alloantigenic stimulation. II. Relationship of the Lyt-2 molecular complex to cytolytic activity, proliferation, and lymphokine secretion.对特定同种异体抗原刺激能自主增殖的细胞溶解性T淋巴细胞克隆。II. Lyt-2分子复合物与细胞溶解活性、增殖及淋巴因子分泌的关系。
J Immunol. 1983 Apr;130(4):1545-51.
6
A rat anti-mouse T4 monoclonal antibody (H129.19) inhibits the proliferation of Ia-reactive T cell clones and delineates two phenotypically distinct (T4+, Lyt-2,3-, and T4-, Lyt-2,3+) subsets among anti-Ia cytolytic T cell clones.一种大鼠抗小鼠T4单克隆抗体（H129.19）可抑制Ia反应性T细胞克隆的增殖，并在抗Ia细胞毒性T细胞克隆中区分出两个表型不同的亚群（T4+、Lyt-2,3-和T4-、Lyt-2,3+）。
J Immunol. 1984 Jun;132(6):2775-82.
7
Monoclonal anti-Lyt-2 antibodies block the activation of cytolytic T lymphocyte precursors.单克隆抗Lyt-2抗体可阻断细胞毒性T淋巴细胞前体的激活。
J Immunol. 1983 Apr;130(4):1552-5.
8
Role of accessory molecules in signal transduction of cytolytic T lymphocyte by anti-T cell receptor and anti-Ly-6.2C monoclonal antibodies.辅助分子在抗T细胞受体和抗Ly-6.2C单克隆抗体介导的细胞毒性T淋巴细胞信号转导中的作用
J Immunol. 1987 Dec 1;139(11):3556-63.
9
Lectin-dependent and anti-CD3 induced cytotoxicity are preferentially mediated by peripheral blood cytotoxic T lymphocytes expressing Leu-7 antigen.凝集素依赖性和抗CD3诱导的细胞毒性优先由表达Leu-7抗原的外周血细胞毒性T淋巴细胞介导。
J Immunol. 1986 Mar 1;136(5):1579-85.
10
Studies on the induction and expression of T cell-mediated immunity. XV. Role of non-MHC papain-sensitive target structures and Lyt-2 antigens in allogeneic and xenogeneic lectin-dependent cellular cytotoxicity (LDCC).T细胞介导免疫的诱导与表达研究。十五、非MHC木瓜蛋白酶敏感靶结构和Lyt-2抗原在同种异体和异种凝集素依赖性细胞毒性（LDCC）中的作用。
J Immunol. 1985 Sep;135(3):1616-23.

引用本文的文献

1
Expression and function of CD8 in a murine T cell hybridoma.CD8在小鼠T细胞杂交瘤中的表达与功能
J Exp Med. 1987 Dec 1;166(6):1747-57. doi: 10.1084/jem.166.6.1747.
2
Costimulatory signal provided by a B-lymphoblastoid cell line and its Ia-negative variant.一种B淋巴母细胞系及其Ia阴性变体提供的共刺激信号。
Proc Natl Acad Sci U S A. 1989 Dec;86(24):10069-73. doi: 10.1073/pnas.86.24.10069.
3
Direct evidence for binding of CD8 to HLA class I antigens.CD8与I类人白细胞抗原结合的直接证据。
J Exp Med. 1989 Jan 1;169(1):149-60. doi: 10.1084/jem.169.1.149.
4
Functional consequences of anti-sense RNA-mediated inhibition of CD8 surface expression in a human T cell clone.反义RNA介导的人T细胞克隆中CD8表面表达抑制的功能后果
J Exp Med. 1988 Oct 1;168(4):1237-45. doi: 10.1084/jem.168.4.1237.
5
The Lyt-2 molecule recognizes residues in the class I alpha 3 domain in allogeneic cytotoxic T cell responses.Lyt-2分子在同种异体细胞毒性T细胞反应中识别I类α3结构域中的残基。
J Exp Med. 1988 Jul 1;168(1):325-41. doi: 10.1084/jem.168.1.325.
6
Isolation and properties of a Lyt-2.1-negative mutant of a Lyt-2.1/Lyt-2.2 CTL line.Lyt-2.1/Lyt-2.2细胞毒性T淋巴细胞系的Lyt-2.1阴性突变体的分离与特性
Immunogenetics. 1991;34(1):42-51. doi: 10.1007/BF00212311.

本文引用的文献

1
Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens.OKT4分子可能参与T细胞对II类HLA抗原的识别。来自针对SB抗原的细胞毒性T淋巴细胞研究的证据。
J Exp Med. 1982 Oct 1;156(4):1065-76. doi: 10.1084/jem.156.4.1065.
2
Clonal heterogeneity in the functional requirement for Lyt-2/3 molecules on cytolytic T lymphocytes: analysis by antibody blocking and selective trypsinization.细胞毒性T淋巴细胞上Lyt-2/3分子功能需求的克隆异质性：通过抗体阻断和选择性胰蛋白酶消化进行分析。
J Exp Med. 1982 Dec 1;156(6):1711-22. doi: 10.1084/jem.156.6.1711.
3
Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+.对HLA - DR6抗原具有同种特异性的长期人类细胞溶解T细胞系为OKT4阳性。
Proc Natl Acad Sci U S A. 1982 Apr;79(7):2365-9. doi: 10.1073/pnas.79.7.2365.
4
Inhibition of murine T cell-mediated cytolysis and T cell proliferation by a rat monoclonal antibody immunoprecipitating two lymphoid cell surface polypeptides of 94 000 and 180 000 molecular weight.一种大鼠单克隆抗体抑制小鼠T细胞介导的细胞溶解和T细胞增殖，该抗体可免疫沉淀两种分子量分别为94000和180000的淋巴样细胞表面多肽。
Eur J Immunol. 1982 Jan;12(1):60-9. doi: 10.1002/eji.1830120112.
5
The Lyt phenotype of a long-term allospecific T cell line. Both helper and killer activities to IA are mediated by Ly-1 cells.长期同种特异性T细胞系的Lyt表型。对IA的辅助和杀伤活性均由Ly-1细胞介导。
Eur J Immunol. 1981 Mar;11(3):175-80. doi: 10.1002/eji.1830110304.
6
Induction of cytolytic T lymphocytes by mitogenic lectins is specifically inhibited by anti-Lyt-2 antibodies.促有丝分裂凝集素诱导的细胞溶解性T淋巴细胞会被抗Lyt-2抗体特异性抑制。
Eur J Immunol. 1983 Jun;13(6):476-80. doi: 10.1002/eji.1830130609.
7
The mechanism of CTL-mediated killing: monoclonal antibody analysis of the roles of killer and target-cell membrane proteins.细胞毒性T淋巴细胞（CTL）介导杀伤的机制：杀伤细胞和靶细胞膜蛋白作用的单克隆抗体分析
Immunol Rev. 1983;72:73-96. doi: 10.1111/j.1600-065x.1983.tb01073.x.
8
Activation of T lymphocytes by lectins and carbohydrate-oxidizing reagents viewed as an immunological recognition of cell-surface modifications seen in the context of "self" major histocompatibility complex antigens.凝集素和碳水化合物氧化试剂对T淋巴细胞的激活，被视为在“自身”主要组织相容性复合体抗原背景下所见到的细胞表面修饰的一种免疫识别。
Eur J Immunol. 1981 Jun;11(6):475-83. doi: 10.1002/eji.1830110607.
9
T lymphocyte-mediated cytolysis. II. Role of target cell histocompatibility antigens in recognition and lysis.T淋巴细胞介导的细胞溶解作用。II. 靶细胞组织相容性抗原在识别与溶解中的作用。
J Immunol. 1981 Aug;127(2):782-7.
10
T cell subsets and the recognition of MHC class.T细胞亚群与主要组织相容性复合体（MHC）类分子的识别
Immunol Rev. 1983;74:129-42. doi: 10.1111/j.1600-065x.1983.tb01087.x.

单克隆抗Lyt-2.2抗体可阻断H-2阴性靶细胞的凝集素依赖性细胞毒性。

Monoclonal anti-Lyt-2.2 antibody blocks lectin-dependent cellular cytotoxicity of H-2-negative target cells.

作者信息

Hünig T

出版信息

J Exp Med. 1984 Feb 1;159(2):551-8. doi: 10.1084/jem.159.2.551.

DOI:10.1084/jem.159.2.551
PMID:6363597
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187235/
Abstract

The hypothesis that blocking of cytotoxic T lymphocyte (CTL)-mediated cytolysis with anti-Lyt-2 antibodies acts at the level of inhibiting the interaction of the Lyt-2-bearing structure with H-2 class I molecules was tested. In agreement with the findings of others, purified anti-Lyt-2.2 inhibited both antigen-specific lysis and lectin-dependent cellular cytotoxicity (LDCC). LDCC of H-2-positive and H-2-negative target cells was similarly inhibited by this antibody. As expected, this effect was specific for CTL expressing the Lyt-2.2 allele, in contrast to blocking with a rat monoclonal antibody to the murine LFA-1 antigen. The implications of this finding for the function of the Lyt-2 antigen in CTL-target cell interaction are discussed.

摘要

用抗Lyt-2抗体阻断细胞毒性T淋巴细胞（CTL）介导的细胞溶解作用于抑制携带Lyt-2结构与H-2 I类分子相互作用水平这一假说得到了验证。与其他人的研究结果一致，纯化的抗Lyt-2.2抑制了抗原特异性溶解和凝集素依赖性细胞毒性（LDCC）。该抗体同样抑制了H-2阳性和H-2阴性靶细胞的LDCC。正如预期的那样，与用抗小鼠LFA-1抗原的大鼠单克隆抗体进行阻断相反，这种效应对于表达Lyt-2.2等位基因的CTL是特异性的。讨论了这一发现对Lyt-2抗原在CTL-靶细胞相互作用中功能的影响。