Masihi K N, Werner H
Zentralbl Bakteriol Orig A. 1978 Jan;240(1):135-42.
Anti-Toxoplasma serum from rabbits or normal Toxoplasma negative serum from humans was administered to NMRI mice by intraperitoneal, intravenous or oral routes. Transfer of immune serum intrapertioneally 48 hours before lethal challenge with cyst forming Alt strain conferred significant resistance to normal recipients as assessed by a 55% reduction in the number of brain cysts and 89% survival rate. Survivors of the groups receiving oral administration of immune or normal serum 48 hours prior to challenge also showed a reduction in the number of brain cysts of 50% and 21% respectively. Animals given immune serum by intrapertioneal or oral routes 48 hours after, or a small intravenous dose one day before challenge showed higher survival rates in comparison to controls but had an "enchancement" of infection as revealed by increased number of brain cysts.
将兔抗弓形虫血清或人正常弓形虫阴性血清通过腹腔内、静脉内或口服途径给予NMRI小鼠。在以形成包囊的Alt株进行致死性攻击前48小时腹腔内注射免疫血清，与正常受体相比，正常受体的脑包囊数量减少55%，存活率为89%，表明具有显著抗性。在攻击前48小时接受口服免疫血清或正常血清的组的幸存者，脑包囊数量也分别减少了50%和21%。在攻击后48小时通过腹腔内或口服途径给予免疫血清的动物，或在攻击前一天给予小剂量静脉注射的动物，与对照组相比存活率更高，但脑包囊数量增加表明感染“增强”。
