Depiante-Depaoli M, Pacheco-Rupil B, Britos S, Casas A
Am J Reprod Immunol (1980). 1984 Jan-Feb;5(1):9-14. doi: 10.1111/j.1600-0897.1984.tb00280.x.
Spleen cells obtained 30 days after the first immunization of rats isoimmunized with an extract of male accessory glands (MAG) were capable of adoptively transferring specific cell-mediated immunity to normal syngenic recipients. Humoral and cell-mediated immune responses were investigated in donor and in the recipient rats that were killed 7 days after intravenous (IV) injection of the cells. In recipient rats the cell-mediated immunity showed multiple ways of expression and in some cases this was exemplified by a sharp increase in regard to the donor's response. Furthermore, a widespread reactivity in the spleen, lymph nodes, and thymus cells was detected. On the contrary, no circulating antibodies to MAG antigens were demonstrated after the spleen cell transfer. Cell separation studies showed that a nylon wool-nonadherent cell was responsible for the transfer of the cell-mediated immune response. This was abrogated by depletion of T lymphocytes and treatment with antirat thymocytes serum and complement. The mechanism of transfer and development of the cell-mediated immunity in recipient rats is discussed.
用雄性副性腺（MAG）提取物对大鼠进行初次免疫30天后获得的脾细胞，能够将特异性细胞介导的免疫过继转移给正常的同基因受体。在静脉注射（IV）这些细胞7天后处死的供体和受体大鼠中，研究了体液免疫和细胞介导的免疫反应。在受体大鼠中，细胞介导的免疫表现出多种表达方式，在某些情况下，这表现为相对于供体反应的急剧增加。此外，在脾、淋巴结和胸腺细胞中检测到广泛的反应性。相反，脾细胞转移后未检测到针对MAG抗原的循环抗体。细胞分离研究表明，尼龙毛非黏附细胞负责细胞介导免疫反应的转移。T淋巴细胞耗竭以及用抗大鼠胸腺细胞血清和补体处理可消除这种转移。本文讨论了受体大鼠中细胞介导免疫的转移和发展机制。
