Yamazaki M, Sakaguchi T
Brain Res Bull. 1986 Aug;17(2):271-4. doi: 10.1016/0361-9230(86)90126-7.
Insulin release was examined in human subjects after lingual applications of D-glucose and its anomers. A dose-dependent increase in the insulin release was noted following the application of equilibrated D-glucose consisting of 36% alpha- and 64% beta-anomer. The response was not reproduced after administration of atropine. The magnitude of insulin release produced by alpha-anomer was different from that induced by beta-anomer in men who could not differentiate between sweetness of the two anomers. Results indicate that recognition of sweetness in the cortex is unrelated to the insulin response, and suggest that a subcortical mechanism may detect qualitative differences in taste and produce the oral phase of insulin secretion via vagus action in humans.
在人类受试者舌部应用D-葡萄糖及其异头物后，对胰岛素释放情况进行了检测。应用由36%的α-异头物和64%的β-异头物组成的平衡D-葡萄糖后，胰岛素释放呈剂量依赖性增加。给予阿托品后未再现该反应。在无法区分两种异头物甜度的男性中，α-异头物产生的胰岛素释放量与β-异头物诱导的不同。结果表明，皮质对甜味的识别与胰岛素反应无关，并提示皮层下机制可能检测到味觉的质性差异，并通过迷走神经作用产生人类胰岛素分泌的口服期。
