Yakimovskii A F, Karpova I V
I. P. Pavlov Institute, Russian Academy of Sciences, Saint Petersburg.
Neurosci Behav Physiol. 1993 Nov-Dec;23(6):497-502. doi: 10.1007/BF01153675.
The effects of daily injections, over the course of 14 days, of 45 micrograms of phenamine, 5 micrograms of haloperidol and naloxone, 15 micrograms of leu-enkephalin and its analog, a tetrapeptide, into the rostral neostriatum have been studied. The chronic stimulation of the dopaminergic system of the striatum induced facilitation of the realization of an active avoidance conditioned reflex, and stimulated exploratory stereotypy, while its blockade led to suppression of conditioned reflex activity against the background of a clearcut rigid akinetic syndrome. The microinjections of leu-enkephalin and naloxone did not substantially alter the behavior, but the injection of the tetrapeptide was accompanied by changes in behavior, with symptoms of catalepsy and hyperkinesia. Injections of phenamine and haloperidol were accompanied by a decrease in the content of dopamine in the striatum and an increase in the level of DOPAC; the injections of enkephalin and naloxone induced changes of the reverse order. The possible causes of the noncorrespondence of the behavioral and neurochemical shifts in the presence of a direct chronic pharmacological action on the mediator of the neostriatum.
研究了在14天的过程中，每天向吻侧新纹状体注射45微克苯丙胺、5微克氟哌啶醇和纳洛酮、15微克亮脑啡肽及其类似物（一种四肽）的效果。纹状体多巴胺能系统的慢性刺激促进了主动回避条件反射的实现，并刺激了探索性刻板行为，而其阻断则导致在明显的强直运动不能综合征背景下条件反射活动的抑制。亮脑啡肽和纳洛酮的微量注射并未显著改变行为，但四肽的注射伴随着行为变化，出现了僵住症和运动亢进症状。苯丙胺和氟哌啶醇的注射伴随着纹状体中多巴胺含量的降低和DOPAC水平的升高；脑啡肽和纳洛酮的注射则引起相反顺序的变化。在对新纹状体介质存在直接慢性药理作用的情况下，行为和神经化学变化不对应的可能原因。
