人类癌基因。
Human oncogenes.
作者信息
Willecke K, Schäfer R
出版信息
Hum Genet. 1984;66(2-3):132-42. doi: 10.1007/BF00286587.
PMID:6370829
Abstract
The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized. Finally, the concerted or sequential action of cellular transforming genes in the multi-step process of carcinogenesis is discussed.
摘要
本文综述了截至1983年秋季发表的关于人类癌基因的信息。对逆转录病毒癌基因、原癌基因和细胞转化基因进行了比较。详细描述了源自ras基因家族的转化基因。总结了原癌基因激活的不同机制。最后，讨论了细胞转化基因在癌症发生多步骤过程中的协同或顺序作用。
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