Subbiah M T, Yunker R L, Hassan A S, Thibert P
Biochim Biophys Acta. 1984 Jul 26;794(3):355-60. doi: 10.1016/0005-2760(84)90001-8.
Streptozotocin-induced diabetes during pregnancy in rats causes a decrease in primary bile acid pool in neonates. To rule out direct drug effect on the fetus as the basis for this change, studies of bile acid pool and composition at birth and during subsequent development was carried out in neonates of spontaneously diabetic Wistar BB rats and compared to control neonates. The cholic acid pool in neonates of diabetic rats was lower when compared to control neonates at birth. The pool of secondary bile acids was markedly increased in neonates of diabetic rats, with increases in lithocholic and 3 beta,12 alpha-dihydroxycholanoic acid. With age, the cholic acid pool of neonates from diabetic rats was increased and at 3 months of age it was actually higher than in control neonates. The pool of chenodeoxycholic at diabetes onset age was lower in neonates of diabetic rats. HDL-cholesterol was lower in neonates of diabetic rats at 1 week, but this reversed at 3 months of age. These studies firmly establish that neonates of diabetic rats have abnormal bile acid pool and composition at birth which changes to adult diabetic pattern with age.
链脲佐菌素诱导的大鼠孕期糖尿病会导致新生大鼠初级胆汁酸池减少。为了排除药物对胎儿的直接作用是这种变化的基础，对自发糖尿病Wistar BB大鼠的新生大鼠出生时及随后发育过程中的胆汁酸池和成分进行了研究，并与对照新生大鼠进行比较。与对照新生大鼠相比，糖尿病大鼠新生大鼠出生时的胆酸池较低。糖尿病大鼠新生大鼠的次级胆汁酸池显著增加，石胆酸和3β，12α-二羟基胆酸增加。随着年龄的增长，糖尿病大鼠新生大鼠的胆酸池增加，在3个月大时实际上高于对照新生大鼠。糖尿病大鼠新生大鼠在糖尿病发病年龄时的鹅去氧胆酸池较低。糖尿病大鼠新生大鼠在1周时高密度脂蛋白胆固醇较低，但在3个月大时这种情况发生了逆转。这些研究确凿地表明，糖尿病大鼠的新生大鼠出生时胆汁酸池和成分异常，随着年龄增长会转变为成年糖尿病模式。
