Bowie W R, Floyd J F, Miller Y, Alexander E R, Holmes J, Holmes K K
Lancet. 1976 Dec 11;2(7998):1276-8. doi: 10.1016/s0140-6736(76)92034-1.
91 men with non-gonococcal urethritis (N.G.U.) were randomly treated with either sulphafurazole (sulfisoxazole), 500 mg orally q.i.d. for 10 days, or an aminocyclitol (streptomycin or spectinomycin), 2 g intramuscularity for 1 to 3 doses at 12 h intervals. Initial urethral cultures were positive for Chlamydia trachomatis (C) in 36 (40%). Ureaplasma urealyticum (U) was isolated from the urethra or urine from20 (95%) of 21 White men in a first episode of N.G.U. who had negative chlamydia cultures. Sulphafurazole, active against C. trachomatis but not U. urealyticum in vitro, produced a clinical response in 7 of 7 men with C+U- N.G.U. and 5 of 19 with C-U+ N.G.U. (P less than 0-01). Aminocyclitols, active against U. urealyticum but relatively inactive against C. trachomatis in vitro produced a clinical response in 0 of 6 men with C+U-N.G.U., 9 of 11 men with C-U+N.G.U. from whom ureaplasma was eradicated (P less than 0-01), and 0 of 8 with C-U+ N.G.U. from whom ureaplasma was not eradicated. C+U+ N.G.U. responded poorly to both antimicrobials alone. These results support the aetiological importance of both C. trachomatis and U. urealyticum in N.G.U.
91例非淋菌性尿道炎（N.G.U.）男性患者被随机分为两组进行治疗，一组口服磺胺异恶唑（sulfisoxazole），500毫克，每日4次，共10天；另一组肌肉注射氨基环醇类药物（链霉素或壮观霉素），2克，每12小时1次，共注射1至3剂。初始尿道培养显示，36例（40%）患者沙眼衣原体（C）呈阳性。在21例首次发作的N.G.U.白人男性中，20例（95%）尿道或尿液中分离出解脲脲原体（U），这些患者衣原体培养为阴性。磺胺异恶唑在体外对沙眼衣原体有活性，但对解脲脲原体无活性，在7例C+U- N.G.U.男性患者中有7例出现临床反应,在19例C-U+ N.G.U.男性患者中有5例出现临床反应（P<0.01）。氨基环醇类药物在体外对解脲脲原体有活性，但对沙眼衣原体相对无活性，在6例C+U- N.G.U.男性患者中无1例出现临床反应，在11例C-U+ N.G.U.且解脲脲原体被根除的男性患者中有9例出现临床反应（P<0.01），在8例C-U+ N.G.U.且解脲脲原体未被根除的男性患者中无1例出现临床反应。C+U+ N.G.U.患者对单独使用这两种抗菌药物的反应均较差。这些结果支持了沙眼衣原体和解脲脲原体在N.G.U.病因学中的重要性。
