Bauer M, zum Winkel K, Tempel M, Kempf B, Fritz P
Onkologie. 1984 Jun;7(3):156-66. doi: 10.1159/000215429.
According to the criteria of Warren and Gates the course of disease of 11972 patients--8099 of them carcinomas under treatment in the Universitäts-Strahlenklinik--were examined in respect to multiple malignomas. In 232 cases such multiple malignomas were diagnosed, corresponding to 2.86%. We found more women (3.49%) than men (2.13%). In 165 cases (67.2%) multiple malignomas appeared metachronically, i.e. after an interval of more than 2 years, 76 (32.8%) of those patients were synchronic multiple malignoma--carriers. In women we found with 3.49% significantly more often metachronic manifestations than in men (2.13%). According to synchronic multiple malignomas we stated that they are to be found in males and females in an equal amount. On the average the second malignoma appeared in males and females 10 years after diagnosis of the primary tumor. Localizations of the multiple malignomas as well as combinations of certain tumors are shown and discussed.
