Zametkin A J, Brown G L, Karoum F, Rapoport J L, Langer D H, Chuang L W, Wyatt R J
Am J Psychiatry. 1984 Sep;141(9):1055-8. doi: 10.1176/ajp.141.9.1055.
Urinary phenethylamine (PEA), an endogenous amine similar to amphetamine in both molecular structure and pharmacological properties, was studied in 12 boys with attention deficit disorder with hyperactivity. d-Amphetamine and placebo were given for 14 days each in a counterbalanced crossover design; double-blind teacher behavior ratings and motor activity measurements were also obtained. Excretion of PEA, phenylacetic acid, creatinine, and d-amphetamine were measured. PEA was significantly increased and phenylacetic acid was unchanged after d-amphetamine administration, and change in PEA excretion correlated significantly with d-amphetamine excretion. There was no significant relationship between either clinical response to drug and change in PEA or phenylacetic acid excretion.
尿苯乙胺（PEA）是一种内源性胺，其分子结构和药理特性与苯丙胺相似。对12名患有注意力缺陷多动障碍的男孩进行了研究。采用平衡交叉设计，分别给予右旋苯丙胺和安慰剂，各为期14天；同时还获得了双盲教师行为评分和运动活动测量结果。测量了PEA、苯乙酸、肌酐和右旋苯丙胺的排泄量。服用右旋苯丙胺后，PEA显著增加，苯乙酸未发生变化，且PEA排泄量的变化与右旋苯丙胺排泄量显著相关。药物的临床反应与PEA或苯乙酸排泄量的变化之间均无显著关系。
