English A, Savage R D, Britton P G, Ward M K, Kerr D N
Br Med J. 1978 Apr 8;1(6117):888-90. doi: 10.1136/bmj.1.6117.888.
In a dialysis centre with a high tap water aluminium content and a known high incidence of dialysis encephalopathy, 29 patients undertaking regular home dialysis, without clinical evidence of encephalopathy, were studied with a battery of psychological tests that have proved useful in detecting early organic intellectual deterioration in other conditions. Full-scale intelligence quotient, as measured by the Wechsler Adult Intelligence Scale, did not differ significantly from that of the normal population, but the patients showed significant deficiencies in three tests of performance--namely, digit symbol, block design, and picture arrangement. The ability to acquire new information in relation to performance was impaired and the abnormality increased with time on dialysis. Such tests should be useful in early detection of dialysis dementia at a reversible stage.
在一个自来水中铝含量高且已知透析性脑病发病率高的透析中心，对29名进行定期家庭透析且无脑病临床证据的患者进行了一系列心理测试，这些测试已被证明在检测其他情况下早期器质性智力衰退方面很有用。用韦氏成人智力量表测量的全量表智商与正常人群没有显著差异，但患者在三项操作测试中表现出显著缺陷，即数字符号、积木图案和图片排列。与操作相关的获取新信息的能力受损，且随着透析时间的延长异常情况加剧。此类测试在可逆阶段早期检测透析性痴呆方面应会很有用。
