梅毒肾病中的循环免疫复合物。一例报告。
Circulating immune complexes in syphilitic nephropathy. A case report.
作者信息
Sølling J, Sølling K, Jacobsen K U, Olsen S, From E
出版信息
Br J Vener Dis. 1978 Feb;54(1):53-6. doi: 10.1136/sti.54.1.53.
Abstract
A case of transient nephrotic syndrome caused by secondary syphilis is described. A renal biopsy was performed revealing subepithelial hump-like electron-dense deposits and fusion of epithelial foot-processes. Complement C1q-binding-activity and anticomplementarity were demonstrated in the blood, indicating the presence of circulating immune complexes. This strongly suggests that circulating immune complexes are significant in the immunopathogenesis of syphilitic nephropathy.
摘要
本文描述了一例由二期梅毒引起的短暂性肾病综合征病例。进行了肾活检，结果显示上皮下驼峰状电子致密沉积物和上皮足突融合。血液中检测到补体C1q结合活性和抗补体活性，表明存在循环免疫复合物。这强烈提示循环免疫复合物在梅毒肾病的免疫发病机制中具有重要意义。
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