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本文引用的文献

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The hydrolysis of rabbit y-globulin and antibodies with crystalline papain.用结晶木瓜蛋白酶对兔γ球蛋白和抗体进行水解。
Biochem J. 1959 Sep;73(1):119-26. doi: 10.1042/bj0730119.
2
Separation of univalent fragments from the bivalent rabbit antibody molecule by reduction of disulfide bonds.通过二硫键还原从二价兔抗体分子中分离单价片段。
Arch Biochem Biophys. 1960 Aug;89:230-44. doi: 10.1016/0003-9861(60)90049-7.
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Binding of homologous and heterologous IgG to Fc receptors on the fetal rabbit yolk sac membrane.同源和异源IgG与胎兔卵黄囊膜上Fc受体的结合。
J Immunol. 1980 Apr;124(4):1562-5.
4
Assay and partial characterization of detergent solubilized rabbit yolk sac membrane Fc receptors.去污剂溶解的兔卵黄囊膜Fc受体的测定及部分特性分析。
J Immunol. 1980 Apr;124(4):1648-55.
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Free thiol groups and labile disulfide bonds in the IgG fraction of human serum.
J Immunol Methods. 1982;50(1):51-6. doi: 10.1016/0022-1759(82)90303-9.
6
Evaluation of the purity of boar sperm plasma membranes prepared by nitrogen cavitation.通过氮气空化制备的公猪精子质膜纯度评估。
Biol Reprod. 1980 Oct;23(3):637-45. doi: 10.1095/biolreprod23.3.637.
7
A collagen-binding protein on the surface of ejaculated rabbit spermatozoa.射出的兔精子表面的一种胶原结合蛋白。
J Cell Biol. 1980 Aug;86(2):529-36. doi: 10.1083/jcb.86.2.529.
8
Binding of fibronectin to Clq; inhibition of binding by aggregated IgG.纤连蛋白与Clq的结合；聚集IgG对结合的抑制作用。
Immunol Commun. 1981;10(7):601-9. doi: 10.3109/08820138109050713.
9
IgG Fc-binding receptors on spermatozoa.
Eur J Immunol. 1980 Dec;10(12):964-5. doi: 10.1002/eji.1830101213.
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Interference with epididymal physiology as possible site of male contraception.
Arch Androl. 1981 Sep;7(2):159-68. doi: 10.3109/01485018108999303.

非免疫性IgG通过二硫键重排与精子表面结合。

Non-immune IgG binding to the surface of spermatozoa by disulphide rearrangement.

作者信息

Richards J M, Witkin S S

出版信息

Clin Exp Immunol. 1984 Nov;58(2):493-501.

PMID:6388924
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577050/
Abstract

The mechanism whereby immunoglobulin binds to the surface of spermatozoa was investigated. IgG reacts with spermatozoa non-specifically via the Fc portion of the molecule, while both IgM and IgA are completely unreactive. This selective binding of IgG is non-competitive, resistant to heat, proteases and non-ionic detergents and is not mediated by an Fc receptor on the sperm surface. Instead, evidence is presented that IgG covalently binds to spermatozoa by an exchange reaction between labile disulphides on both the sperm surface and IgG-Fc. It is calculated that there are 3 X 10(11) exchangeable disulphide bonds per bull spermatozoon.

摘要

对免疫球蛋白与精子表面结合的机制进行了研究。IgG通过分子的Fc部分与精子发生非特异性反应，而IgM和IgA则完全无反应。IgG的这种选择性结合是非竞争性的，对热、蛋白酶和非离子去污剂具有抗性，且不是由精子表面的Fc受体介导的。相反，有证据表明IgG通过精子表面和IgG-Fc上不稳定二硫键之间的交换反应与精子共价结合。据计算，每头公牛精子有3×10¹¹个可交换二硫键。