Bosch A, Lucena F, Parés R, Jofre J
J Immunopharmacol. 1984;6(4):323-8. doi: 10.3109/08923978409028607.
The compensatory effect of a bacterial lysate, Broncho-Vaxom (BV) on the immunosuppressive action of cyclophosphamide (CY) was investigated. In CY immunosuppressed mice, BV treated animals recovered to normal levels of IgM and IgG in serum as well of IgA and IgG in gut secretions significantly earlier than controls. Furthermore, normal cell proliferation in thymus, as estimated by measuring the relative size of this organ was achieved earlier in BV treated mice than in control mice. Oral treatment with BV restores the number of IgM anti SRBC producing cells in spleen, in CY immunosuppressed mice. Since immunosuppression induced by CY increases the susceptibility to various infections, we tested in immunosuppressed animals the protective effect of BV towards IP challenge infections with Streptococcus pneumoniae, Staphylococcus aureus, Klebsiella pneumoniae var ozaenae, Pseudomonas aeruginosa and Candida albicans. BV led to an enhanced resistance towards both pneumococci and staphylococci challenge infections but not to the other challenge microorganisms.
研究了细菌裂解物泛福舒（BV）对环磷酰胺（CY）免疫抑制作用的补偿效应。在CY免疫抑制的小鼠中，BV处理的动物血清中IgM和IgG以及肠道分泌物中IgA和IgG恢复到正常水平的时间明显早于对照组。此外，通过测量胸腺相对大小评估，BV处理的小鼠胸腺中正常细胞增殖的恢复时间早于对照小鼠。对CY免疫抑制的小鼠口服BV可恢复脾脏中产生抗绵羊红细胞IgM的细胞数量。由于CY诱导的免疫抑制会增加对各种感染的易感性，我们在免疫抑制动物中测试了BV对肺炎链球菌、金黄色葡萄球菌、鼻硬结克雷伯菌、铜绿假单胞菌和白色念珠菌腹腔注射感染的保护作用。BV增强了对肺炎球菌和葡萄球菌攻击感染的抵抗力，但对其他攻击微生物没有作用。
