Fortis A A, Lianou P E, Papavassilliou J T
Centre for Infectious Diseases, Department of Microbiology, Athens Medical School, Athens University, Greece.
APMIS. 1998 Apr;106(4):441-8.
We examined the in vitro effect of Broncho Vaxom (BV) (an immunobiotherapeutic preparation containing a lysate made from bacteria often involved in respiratory tract infections) on adherence of Staphylococcus aureus, Klebsiella pneumoniae and Candida albicans to human buccal epithelial cells (BEC) of healthy volunteers and HIV carriers. We also examined the ex vivo effect of ascorbic acid on the adherence of the same microorganisms to BEC of HIV carriers. The study reached the following conclusions: The presence of BV in vitro significantly reduces the adherence of the tested strains to BEC from healthy persons and HIV carriers. No significant difference was observed between healthy persons and HIV carriers regarding the adherence of the tested strains to BEC. Significant difference in the adherence of the tested strains to BEC was observed between HIV carriers who had been taking ascorbic acid over a 3-month period and those who had not. There was no further reduction in the adherence of the tested strains to BEC from HIV carriers who had been taking ascorbic acid in the presence of BV in vitro.
我们研究了泛福舒（BV）（一种免疫生物治疗制剂，含有由常见于呼吸道感染的细菌制成的裂解物）对金黄色葡萄球菌、肺炎克雷伯菌和白色念珠菌黏附健康志愿者及HIV携带者的人颊上皮细胞（BEC）的体外作用。我们还研究了维生素C对相同微生物黏附HIV携带者BEC的离体作用。该研究得出以下结论：体外存在BV可显著降低受试菌株对健康人和HIV携带者BEC的黏附。在受试菌株对BEC的黏附方面，健康人与HIV携带者之间未观察到显著差异。在服用维生素C 3个月的HIV携带者与未服用者之间，观察到受试菌株对BEC的黏附存在显著差异。在体外存在BV的情况下，服用维生素C的HIV携带者的受试菌株对BEC的黏附没有进一步降低。
