Kotulová D, Zalkovicová M, Stefanovic J
Department of Microbiology and Immunology, Medical Faculty, Comenius University, Bratislava, Czechoslovakia.
Folia Microbiol (Praha). 1988;33(5):401-6. doi: 10.1007/BF02925851.
Single and repeated intravenous administration of cyclophosphamide significantly decreased the candidacidal activity of rabbit peritoneal macrophages. Using higher doses of the drug, a more pronounced decrease, persisting up to 10 d, was observed. The phagocytic index has not changed significantly 10 d after cyclophosphamide injection as compared with controls. No changes in the phagocytic activity were recorded. The decreased candidacidal activity may be one of the causes of serious microbial infections in cyclophosphamide-treated patients.
单次及重复静脉注射环磷酰胺可显著降低兔腹腔巨噬细胞的杀念珠菌活性。使用更高剂量的该药物时，观察到杀念珠菌活性有更显著的降低，且这种降低可持续长达10天。与对照组相比，环磷酰胺注射10天后吞噬指数无显著变化。未记录到吞噬活性的改变。杀念珠菌活性降低可能是环磷酰胺治疗患者发生严重微生物感染的原因之一。
