对人胰岛素基因侧翼一个1963bp多态性区域的分析。
Analysis of a 1963-bp polymorphic region flanking the human insulin gene.
作者信息
Owerbach D, Aagaard L
出版信息
Gene. 1984 Dec;32(3):475-9. doi: 10.1016/0378-1119(84)90021-0.
PMID:6397408
Abstract
The nucleotide sequence of a long polymorphic region located 365 bp upstream from the human insulin gene is reported. The region is composed of 139 repeating sequences whose consensus structure is related to ACAGGGGTGTGGGG. Expansion in the number of repeating sequences appears to have taken place through duplication and triplication of 112-141-bp regions. However, ancestral polymorphic regions containing additions or deletions of 50 bp or more were not detected in two previous generations.
摘要
报道了位于人类胰岛素基因上游365 bp处一个长多态性区域的核苷酸序列。该区域由139个重复序列组成，其共有结构与ACAGGGGTGTGGGG相关。重复序列数量的增加似乎是通过112 - 141 bp区域的重复和三倍化发生的。然而，在前两代中未检测到包含50 bp或更多碱基插入或缺失的祖先多态性区域。
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