Deloron P, Le Bras J, Coulanges P, Coulaud J P
Arch Inst Pasteur Madagascar. 1984;51(1):81-7.
In a nine month fields study in 1983 in Madagascar, in vitro sensitivity to others drugs than 4 aminoquinolines were tested for 39 Plasmodium falciparum isolates, including 2 chloroquine resistant ones. Sensitivity to quinine, mefloquine and halofantrine were recorded from 28, 39 and 11 of these isolates respectively. IC50 with semi-microtest were under 20 nM/1 for mefloquine, under 12 nM/1 for halofantrine and under 560 nM/1 for quinine. All these values are under maximal values observed elsewhere with isolates coming from patients successfully treated with the three drugs.
1983年在马达加斯加进行了为期九个月的实地研究，对39株恶性疟原虫分离株（包括2株氯喹耐药株）进行了除4-氨基喹啉以外其他药物的体外敏感性测试。分别从其中28株、39株和11株分离株记录了对奎宁、甲氟喹和卤泛群的敏感性。半微量试验测得甲氟喹的IC50低于20 nM/1，卤泛群低于12 nM/1，奎宁低于560 nM/1。所有这些数值均低于其他地方用这三种药物成功治疗的患者分离株所观察到的最大值。
