Ough Y D, Miller W M, Leeb B, Holbrook D L, Klos J R
Cancer. 1983 Feb 15;51(4):623-30. doi: 10.1002/1097-0142(19830215)51:4<623::aid-cncr2820510414>3.0.co;2-c.
Immunoblastic lymphoma (IBL) showing features of angioimmunoblastic lymphadenopathy (AIBL) is described. Abundant eosinophilic extracellular deposits were present in lymph nodes. Electron microscopic and immunoperoxidase studies showed this material was composed of degenerating tumor cells and polyclonal immunoglobulins (Mu and Alpha heavy chains and Kappa and Lambda light chains). Numerous arborizing vessels were thickened with monoclonal IgM(K) immunoglobulins. The tumor cell lysis and degeneration are though to be due to the high cell turnover and immune reaction to unrecognized substances.
描述了表现血管免疫母细胞性淋巴结病（AIBL）特征的免疫母细胞淋巴瘤（IBL）。淋巴结中存在大量嗜酸性细胞外沉积物。电子显微镜和免疫过氧化物酶研究表明，这种物质由退化的肿瘤细胞和多克隆免疫球蛋白（μ和α重链以及κ和λ轻链）组成。许多分支状血管因单克隆IgM（κ）免疫球蛋白而增厚。肿瘤细胞的溶解和退化被认为是由于高细胞周转率以及对未识别物质的免疫反应所致。
