Oka Y, Ghishan F K, Greene H L, Orth D N
Endocrinology. 1983 Mar;112(3):940-4. doi: 10.1210/endo-112-3-940.
Mouse epidermal growth factor/urogastrone (EGF/UG), administered sc in a dose of 0.1 microgram/g BW twice daily for 3 days, increased intestinal weight per unit length, lactase specific activity, and net calcium transport in normal 2-week-old suckling rats, but had no effect on maltase or sucrase specific activity. In normal 3-week-old weanling rats, the intestinal function of which is essentially fully mature, EGF/UG had no effect. These results suggest that EGF/UG, either secreted endogenously or ingested in breast milk, may have a role in both the morphological and functional maturation of the suckling rat intestine.
小鼠表皮生长因子/尿抑胃素（EGF/UG），以0.1微克/克体重的剂量皮下注射，每日两次，共3天，可增加正常2周龄哺乳大鼠的单位长度肠重量、乳糖酶比活性和净钙转运，但对麦芽糖酶或蔗糖酶比活性无影响。在正常3周龄断奶大鼠中，其肠道功能基本已完全成熟，EGF/UG无作用。这些结果表明，内源性分泌或经母乳摄入的EGF/UG可能在哺乳大鼠肠道的形态和功能成熟中发挥作用。
