Cohen J C, Murphey-Corb M
Nature. 1983 Jan 13;301(5896):129-32. doi: 10.1038/301129a0.
The infection of cultured human cells with baboon endogenous virus (BEV) frequently leads to an association of viral DNA with a specific genetic locus (termed BEVI, for baboon endogenous virus infection) on chromosome 6. Restriction endonuclease digestion of DNA from BEV-infected human cells and their derived somatic cell clones frequently revealed a common cellular DNA sequence in the proximity of one of the junctions between cellular DNA and the integrated virus. We propose that a short cellular DNA sequence, repeated on chromosome 6 and separated by unique DNA sequences, presents a high-affinity target for the integration of BEV in human cells.
用狒狒内源性病毒（BEV）感染培养的人类细胞，常常会导致病毒DNA与6号染色体上的一个特定基因位点（称为BEVI，即狒狒内源性病毒感染位点）发生关联。对来自BEV感染的人类细胞及其衍生的体细胞克隆的DNA进行限制性内切酶消化，常常会在细胞DNA与整合病毒之间的一个连接点附近发现一个共同的细胞DNA序列。我们提出，一个在6号染色体上重复且被独特DNA序列隔开的短细胞DNA序列，是BEV在人类细胞中整合的高亲和力靶点。
