Mizoi K, Yoshimoto T, Suzuki J
No Shinkei Geka. 1981 Jul;9(8):905-9.
Using the "canine model of complete ischemic brain regulated with a perfusion method" in which it is possible to control the degree of blood flow to a cerebral hemisphere via a perfusion pump, the effects of mannitol (which acts as a free radical scavenger) and FC (which has 0.1 micrometer of average particle size and a high oxygen-carrying capacity) on cerebral ischemia were investigated. After pretreatment with the drugs, blood flow was reduced via the pump to 1/10 of the normal flow volume and 1 hr later, return to a normal flow was allowed. Subsequent changes in electrical activity were observed and the effects of the drugs evaluated. In the control group, no recovery of electrical activity was seen, but in the animals treated with either mannitol or FC, incomplete, yet distinct recovery was apparent. In the animals administered with mannitol together with FC, however, marked recovery was evident. These experimental results indicated that a combined administration of FC and mannitol is effective in protecting the brain from cerebral ischemia.
使用“通过灌注方法调节的完全缺血性脑犬模型”，在此模型中可以通过灌注泵控制流向大脑半球的血流量，研究了甘露醇（作为自由基清除剂）和氟碳化合物（平均粒径为0.1微米且具有高携氧能力）对脑缺血的影响。在用药物预处理后，通过泵将血流量降低至正常流量的1/10，1小时后，恢复至正常流量。观察随后的电活动变化并评估药物的效果。在对照组中，未见电活动恢复，但在使用甘露醇或氟碳化合物治疗的动物中，明显出现了不完全但明显的恢复。然而，在同时给予甘露醇和氟碳化合物的动物中，明显出现了显著的恢复。这些实验结果表明，联合使用氟碳化合物和甘露醇可有效保护大脑免受脑缺血的影响。
