Nattie E E
J Appl Physiol Respir Environ Exerc Physiol. 1983 Jan;54(1):3-12. doi: 10.1152/jappl.1983.54.1.3.
This review emphasizes the importance of strong ions in the regulation of cerebrospinal fluid (CSF) acid-base balance. In a solution like CSF that is devoid of nonbicarbonate buffers. [H+] and [HCO-3] are dependent variables, the independent variables being the CO2 partial pressure (PCO2) and the strong ion difference. Any measureable changes in CSF [HCO-3] and any change in [H+] that occur independent of changes in PCO2 must be accompanied by, if not caused by, changes in strong ions. The role of H+ and HCO-3 vs. strong ions in the ionic mechanisms of CSF acid-base regulation is unknown. For example, these mechanisms could depend only on changes in strong ions that accompany acid-base disorders, or they could be triggered by changes in [H+] or PCO2. These ideas are presented within the context of current concepts concerning the relationship of CSF to brain interstitial fluid (ISF) and the importance of choroid plexus and blood-brain barrier mechanisms in determining CSF and ISF ionic composition. Studies concerning CSF strong ions in normal and abnormal acid-base states are reviewed.
本综述强调强离子在调节脑脊液（CSF）酸碱平衡中的重要性。在像脑脊液这样缺乏非碳酸氢盐缓冲剂的溶液中，[H⁺]和[HCO₃⁻]是因变量，自变量是二氧化碳分压（PCO₂）和强离子差。脑脊液中[HCO₃⁻]的任何可测量变化以及独立于PCO₂变化而发生的[H⁺]的任何变化，即使不是由强离子变化引起的，也必定伴随着强离子的变化。H⁺和HCO₃⁻与强离子在脑脊液酸碱调节离子机制中的作用尚不清楚。例如，这些机制可能仅取决于伴随酸碱紊乱的强离子变化，或者可能由[H⁺]或PCO₂的变化触发。这些观点是在当前关于脑脊液与脑间质液（ISF）关系的概念以及脉络丛和血脑屏障机制在决定脑脊液和ISF离子组成中的重要性的背景下提出的。本文综述了关于正常和异常酸碱状态下脑脊液强离子的研究。
