Nattie E E, Romer L
Respir Physiol. 1978 May;33(2):177-98. doi: 10.1016/0034-5687(78)90068-3.
We have studied in anesthetized cats the response of CSF HCO3- to (1) an increase in CSF PCO2, plasma HCO3- controlled at the normal value; (2) an increase in plasma HCO3-, CSF PCO2 controlled at the normal value; and (3) an increase in both CSF PCO2 and plasma HCO3-. Plasma HCO3- was controlled via HCO3-/Cl- exchange without altering plasma Na concentration or osmolarity using the technique of peritoneal dialysis. The results suggest that CSF HCO3- regulation in these conditions is dependent on (1) a PCO2-dependent process in which HCO3- ions are formed in brain cells or choroid plexus and (2) an ionic movement of HCO3- from plasma to CSF dependent on an increase in plasma HCO3-. The first process is largely completed by 3 hours; the second takes 6 hours or more. An analysis of plasma and CSF HCO3-, Cl- and unmeasured anions (UA), (Na+ + K+ -CL- -HCO3-), suggests that CSF HCO3- regulation may be complex involving ionic exchanges of three or more anions between brain extracellular fluid, plasma and brain cells.
我们在麻醉猫身上研究了脑脊液（CSF）中HCO₃⁻对以下情况的反应：（1）脑脊液PCO₂升高，血浆HCO₃⁻控制在正常水平；（2）血浆HCO₃⁻升高，脑脊液PCO₂控制在正常水平；（3）脑脊液PCO₂和血浆HCO₃⁻均升高。通过腹膜透析技术，利用HCO₃⁻/Cl⁻交换来控制血浆HCO₃⁻，而不改变血浆钠浓度或渗透压。结果表明，在这些情况下，脑脊液HCO₃⁻的调节依赖于：（1）一个依赖PCO₂的过程，其中HCO₃⁻离子在脑细胞或脉络丛中形成；（2）HCO₃⁻从血浆到脑脊液的离子移动，这依赖于血浆HCO₃⁻的增加。第一个过程在3小时内基本完成；第二个过程需要6小时或更长时间。对血浆和脑脊液中的HCO₃⁻、Cl⁻和未测定阴离子（UA）、（Na⁺ + K⁺ - Cl⁻ - HCO₃⁻）的分析表明，脑脊液HCO₃⁻的调节可能很复杂，涉及脑细胞外液、血浆和脑细胞之间三种或更多阴离子的离子交换。
