Adler K B, Winn W C, Alberghini T V, Craighead J E
JAMA. 1983 Mar 25;249(12):1615-7.
Cell-free filtrates of broth cultures from 11 of 18 strains of Pseudomonas aeruginosa isolated from patients with cystic fibrosis (CF) (or from patients without CF) increased substantially the secretion of mucin by explants of trachea from guinea pigs and human tracheal tissue obtained at autopsy. The effect was not related to the mucoid nature of the isolates, was not destroyed by heating at 90 degrees C for 30 minutes, and was not dependent on serotype. As P aeruginosa commonly infects the respiratory tracts of persons with CF, elaboration of an extracellular product that stimulates mucin secretion could play a role in the pathogenesis of the disease in the airways.
从囊性纤维化（CF）患者（或非CF患者）中分离出的18株铜绿假单胞菌中，有11株肉汤培养物的无细胞滤液显著增加了豚鼠气管外植体和尸检获得的人气管组织中粘蛋白的分泌。这种作用与分离株的粘液样性质无关，在90摄氏度加热30分钟不会被破坏，也不依赖于血清型。由于铜绿假单胞菌通常感染CF患者的呼吸道，一种能刺激粘蛋白分泌的细胞外产物的产生可能在气道疾病的发病机制中起作用。
