Arko R J, Wong K H, Smith S J, Finley-Price K G
Br J Vener Dis. 1983 Apr;59(2):94-7. doi: 10.1136/sti.59.2.94.
Different brands of vaginal tampons varied significantly (p less than 0.0001) in their anti-bacterial effects when tested with 46 strains of Neisseria gonorrhoeae. Gonococcal strains recovered from patients with disseminated infections were substantially more sensitive to the anti-bacterial effects of tampons than were strains from patients with uncomplicated genital infections. Strains from patients with pelvic inflammatory disease were moderately sensitive. Tampons showing strong in-vitro antigonococcal effects were also generally effective in vivo in eliminating gonococcal infections from subcutaneous chambers in mice. Extracts of the Rely tampon showed no in-vitro antigonococcal effect, however, but did induce antibacterial activity when injected into subcutaneous chambers in mice. These results emphasise the importance of both in-vitro as well as in-vivo testing of tampon materials to elucidate more fully the nature of their antibacterial effects and their potential for affecting vaginal pathogens and disease processes.
用46株淋病奈瑟菌进行测试时，不同品牌的阴道棉条抗菌效果差异显著（p小于0.0001）。从播散性感染患者中分离出的淋球菌菌株对棉条抗菌效果的敏感性显著高于单纯生殖器感染患者的菌株。盆腔炎患者的菌株敏感性中等。体外抗淋球菌作用强的棉条在体内通常也能有效消除小鼠皮下腔室中的淋球菌感染。然而，高洁丝棉条提取物在体外没有抗淋球菌作用，但注入小鼠皮下腔室时会诱导抗菌活性。这些结果强调了对棉条材料进行体外和体内测试的重要性，以便更全面地阐明其抗菌作用的本质以及影响阴道病原体和疾病进程的潜力。
