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2
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Measurement of growth-inhibiting (bactericidal) antibodies in patients with meningococcal meningitis and in subjects immunized with meningococcal polysaccharide vaccine by a [3H]thymidine assay.通过[3H]胸腺嘧啶核苷测定法对患脑膜炎球菌性脑膜炎的患者及接种脑膜炎球菌多糖疫苗的受试者体内生长抑制（杀菌）抗体进行测量。
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Class-specific antibody response to group B Neisseria meningitidis capsular polysaccharide: use of polylysine precoating in an enzyme-linked immunosorbent assay.针对B群脑膜炎奈瑟菌荚膜多糖的类特异性抗体反应：在酶联免疫吸附测定中使用聚赖氨酸预包被
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本文引用的文献

1
Analysis of outer membrane components of Escherichia coli ML308 225 and of a serum-resistant mutant.大肠杆菌ML308 225及血清抗性突变体的外膜成分分析。
Infect Immun. 1980 May;28(2):387-92. doi: 10.1128/iai.28.2.387-392.1980.
2
Plasmid-determined resistance to serum bactericidal activity: a major outer membrane protein, the traT gene product, is responsible for plasmid-specified serum resistance in Escherichia coli.质粒介导的对血清杀菌活性的抗性：一种主要外膜蛋白，即traT基因产物，负责大肠杆菌中质粒特异性的血清抗性。
Infect Immun. 1980 May;28(2):359-67. doi: 10.1128/iai.28.2.359-367.1980.
3
Homologous species restriction in lysis of erythrocytes by terminal complement proteins.终末补体蛋白对红细胞溶解的同源物种限制
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5118-21. doi: 10.1073/pnas.78.8.5118.
4
Measurement of antibodies to meningococcal group B polysaccharide: low avidity binding and equilibrium binding constants.B群脑膜炎球菌多糖抗体的测定：低亲和力结合及平衡结合常数
J Immunol. 1982 Nov;129(5):2172-8.
5
Natural bactericidal activity of human serum against Neisseria meningitidis isolates of different serogroups and serotypes.人血清对不同血清群和血清型脑膜炎奈瑟菌分离株的天然杀菌活性。
Infect Immun. 1982 Jul;37(1):132-7. doi: 10.1128/iai.37.1.132-137.1982.
6
Serotype determinant protein of Neisseria Meningitidis. Large scale preparation by direct detergent treatment of the bacterial cells.
Acta Pathol Microbiol Scand C. 1981 Apr;89(2):69-78.
7
Meningococcal meningitis in familial deficiency of the fifth component of complement.补体第五成分家族性缺陷中的脑膜炎球菌性脑膜炎
Pediatrics. 1981 Jun;67(6):882-6.
8
Evaluation of immunotherapeutic approaches for the potential treatment of infections caused by K1-positive Escherichia coli.评估用于潜在治疗由K1阳性大肠杆菌引起的感染的免疫治疗方法。
J Infect Dis. 1983 Jan;147(1):68-76. doi: 10.1093/infdis/147.1.68.
9
Properties of 19S antibodies in complement fixation. II. Selective inactivation of a complement-fixing site by urea.补体结合中19S抗体的特性。II. 尿素对补体结合位点的选择性灭活
J Immunol. 1968 Oct;101(4):695-701.
10
Human immunity to the meningococcus. II. Development of natural immunity.人类对脑膜炎球菌的免疫力。II. 自然免疫力的发展
J Exp Med. 1969 Jun 1;129(6):1327-48. doi: 10.1084/jem.129.6.1327.

补体来源在人源抗体及抗B群脑膜炎球菌多糖鼠单克隆抗体杀菌活性中的重要性

Importance of complement source in bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide.

作者信息

Zollinger W D, Mandrell R E

出版信息

Infect Immun. 1983 Apr;40(1):257-64. doi: 10.1128/iai.40.1.257-264.1983.

DOI:10.1128/iai.40.1.257-264.1983
PMID:6403466
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC264843/
Abstract

The bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide was investigated as a function of the complement source. The immunoglobulin M murine monoclonal antibody 2-2-B was shown by several different methods to be highly specific for meningococcal group B and Escherichia coli K1 capsular polysaccharides. It had strong bactericidal activity in conjunction with either rabbit or human complement, but gave a higher titer with rabbit complement. A strong prozone was observed in each case. Human postvaccination antibody to meningococcal group B polysaccharide was strongly bactericidal with rabbit complement, but had little or no bactericidal activity in conjunction with human complement. Antibodies in adult normal human sera that were bactericidal with rabbit complement were also found to be predominantly directed against the meningococcal group B capsular polysaccharide. Human antibodies that were bactericidal with human complement appeared to be primarily directed against noncapsular antigens.

摘要

研究了针对B群脑膜炎球菌多糖的人源抗体和鼠源单克隆抗体的杀菌活性与补体来源的关系。通过几种不同方法表明，免疫球蛋白M鼠源单克隆抗体2-2-B对B群脑膜炎球菌和大肠杆菌K1荚膜多糖具有高度特异性。它与兔补体或人补体结合时均具有很强的杀菌活性，但与兔补体结合时效价更高。在每种情况下均观察到明显的前带现象。接种疫苗后的人源抗B群脑膜炎球菌多糖抗体与兔补体结合时具有很强的杀菌活性，但与人类补体结合时几乎没有或没有杀菌活性。还发现，成人正常人血清中与兔补体结合具有杀菌活性的抗体主要针对B群脑膜炎球菌荚膜多糖。与人类补体结合具有杀菌活性的人源抗体似乎主要针对非荚膜抗原。