补体来源在人源抗体及抗B群脑膜炎球菌多糖鼠单克隆抗体杀菌活性中的重要性
Importance of complement source in bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide.
作者信息
Zollinger W D, Mandrell R E
出版信息
Infect Immun. 1983 Apr;40(1):257-64. doi: 10.1128/iai.40.1.257-264.1983.
Abstract
The bactericidal activity of human antibody and murine monoclonal antibody to meningococcal group B polysaccharide was investigated as a function of the complement source. The immunoglobulin M murine monoclonal antibody 2-2-B was shown by several different methods to be highly specific for meningococcal group B and Escherichia coli K1 capsular polysaccharides. It had strong bactericidal activity in conjunction with either rabbit or human complement, but gave a higher titer with rabbit complement. A strong prozone was observed in each case. Human postvaccination antibody to meningococcal group B polysaccharide was strongly bactericidal with rabbit complement, but had little or no bactericidal activity in conjunction with human complement. Antibodies in adult normal human sera that were bactericidal with rabbit complement were also found to be predominantly directed against the meningococcal group B capsular polysaccharide. Human antibodies that were bactericidal with human complement appeared to be primarily directed against noncapsular antigens.
摘要
研究了针对B群脑膜炎球菌多糖的人源抗体和鼠源单克隆抗体的杀菌活性与补体来源的关系。通过几种不同方法表明，免疫球蛋白M鼠源单克隆抗体2-2-B对B群脑膜炎球菌和大肠杆菌K1荚膜多糖具有高度特异性。它与兔补体或人补体结合时均具有很强的杀菌活性，但与兔补体结合时效价更高。在每种情况下均观察到明显的前带现象。接种疫苗后的人源抗B群脑膜炎球菌多糖抗体与兔补体结合时具有很强的杀菌活性，但与人类补体结合时几乎没有或没有杀菌活性。还发现，成人正常人血清中与兔补体结合具有杀菌活性的抗体主要针对B群脑膜炎球菌荚膜多糖。与人类补体结合具有杀菌活性的人源抗体似乎主要针对非荚膜抗原。
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