Karpov Iu A, Noeva E A
Kardiologiia. 1983 Jan;23(1):60-5.
The hemodynamic effect of the skin nitroglycerin ointment was studied in 16 patients with coronary disease (12 with acute myocardial infarction, and 4 with nonstable angina pectoris). All the patients were subject to catheterization of the pulmonary artery to determine the end diastolic pressure (EDPPA) and cardiac output with the method of thermal dilution. When the initial EDPPA was more than 18 mm Hg it decreased by 34%, the systolic arterial pressure decreased by 11%, the cardiac index (CI) being raised by 23%, after application of 1.5-3 inches of the ointment. The hemodynamic shifts persisted during 4h. In patients with normal EDPPA, lowering of this parameter by 40% and of CI by 19% was recorded. The heart rate in both the groups was not significantly altered. The nitroglycerin ointment did not induce unfavourable hemodynamic shifts in patients with no signs of cardiac failure. In those with myocardial infarction, complicated by circulatory insufficiency, the ointment improved the functional state of the left ventricle.
对16例冠心病患者（12例急性心肌梗死患者和4例不稳定型心绞痛患者）研究了皮肤硝酸甘油软膏的血流动力学效应。所有患者均接受肺动脉导管插入术，采用热稀释法测定舒张末期压力（EDPPA）和心输出量。当初始EDPPA超过18 mmHg时，涂抹1.5 - 3英寸软膏后，EDPPA下降34%，收缩动脉压下降11%，心脏指数（CI）升高23%。血流动力学变化持续4小时。在EDPPA正常的患者中，该参数降低40%，CI降低19%。两组患者的心率均无明显变化。硝酸甘油软膏在无心力衰竭迹象的患者中未引起不利的血流动力学变化。在合并循环功能不全的心肌梗死患者中，该软膏改善了左心室的功能状态。
