Urist M R, DeLange R J, Finerman G A
Science. 1983 May 13;220(4598):680-6. doi: 10.1126/science.6403986.
Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.
骨形态发生蛋白和骨源性生长因子是用于研究诱导细胞分化和控制细胞增殖的局部机制的生化工具。骨形态发生蛋白不可逆地诱导血管周围间充质型细胞分化为成骨祖细胞。骨源性生长因子由成骨祖细胞分泌并作用于成骨祖细胞，刺激DNA合成。骨生成和再生归因于骨形态发生蛋白和骨源性生长因子的协同作用。
