亚胺培南（N-甲酰亚胺基硫霉素）对肠球菌的比较活性及其与氨基糖苷类药物的相互作用。

Comparative activity of imipenem (N-formimidoyl thienamycin) on enterococci and its interactions with aminoglycosides.

作者信息

Aznar J, García Iglesias M C, Perea E J

出版信息

J Antimicrob Chemother. 1984 Feb;13(2):129-32. doi: 10.1093/jac/13.2.129.

DOI:10.1093/jac/13.2.129

Abstract

Activity of imipenem (N-formimidoyl thienamycin, ampicillin and vancomycin against 27 Streptococcus faecalis and 5 Str. faecium was determined. Also evaluated were the interactions of imipenem, ampicillin and vancomycin with streptomycin or amikacin or sissomicin. Imipenem showed the most inhibitory activity against Str. faecalis with MIC50 and MIC90 values 0.5 and 2 mg/l respectively, Str. faecium strains were less susceptible to imipenem with MIC50/MIC90 values of 2/16 mg/l. Imipenem showed good bactericidal activity against both groups of strains with MBC50/MBC90 values of 1/4 and 4/16 mg/l respectively. The most favourable interactions (synergy and addition) of imipenem were with streptomycin (72.2%) and sissomicin (53.2%). Combinations containing amikacin were the least favourable. Similar results were obtained with these combinations against Str. faecium.

摘要

测定了亚胺培南（N-甲酰亚胺硫霉素）、氨苄西林和万古霉素对27株粪肠球菌和5株屎肠球菌的活性。还评估了亚胺培南、氨苄西林和万古霉素与链霉素、阿米卡星或西索米星的相互作用。亚胺培南对粪肠球菌的抑制活性最强，其MIC50和MIC90值分别为0.5和2mg/L，屎肠球菌菌株对亚胺培南的敏感性较低，MIC50/MIC90值为2/16mg/L。亚胺培南对两组菌株均显示出良好的杀菌活性，MBC50/MBC90值分别为1/4和4/16mg/L。亚胺培南最有利的相互作用（协同和相加）是与链霉素（72.2%）和西索米星（53.2%）。含阿米卡星的组合最不利。这些组合对屎肠球菌也得到了类似的结果。