Winslow R E, Dean R E, Harley J W
Arch Surg. 1983 May;118(5):651-5. doi: 10.1001/archsurg.1983.01390050117023.
A prospective, randomized, double-blind clinical study was performed to determine the efficacy of perioperative systemic antibiotics in preventing infection after appendectomy for acute nonperforating appendicitis. One hundred three patients received three doses of either placebo (saline, n = 52) or cefoxitin sodium (n = 51). The two groups were similar with regard to age distribution, sex ratio, duration of operation, pathologic condition of appendix, and hospital stay. Postoperative wound infections were detected in 9.6% of the placebo-treated patients, whereas none occurred in the cefoxitin group. All but one infection appeared after discharge. Cost analysis identified a net savings of $ 84 per patient with the use of prophylactic antibiotics. Septic morbidity after appendectomy for nonperforating appendicitis is significantly reduced by systemic antibiotics, and brief administration of a single broad-spectrum agent (cefoxitin) is effective prophylaxis.
进行了一项前瞻性、随机、双盲临床研究，以确定围手术期全身使用抗生素对急性非穿孔性阑尾炎阑尾切除术后预防感染的疗效。103例患者接受了三剂安慰剂（生理盐水，n = 52）或头孢西丁钠（n = 51）治疗。两组在年龄分布、性别比例、手术时间、阑尾病理状况和住院时间方面相似。安慰剂治疗组9.6%的患者发生了术后伤口感染，而头孢西丁组无一例发生。除1例感染外，所有感染均在出院后出现。成本分析表明，使用预防性抗生素每位患者可节省84美元。全身使用抗生素可显著降低非穿孔性阑尾炎阑尾切除术后的脓毒症发病率，短期使用单一广谱药物（头孢西丁）是有效的预防措施。
