Morito T, Kano K, Milgrom F
Int Arch Allergy Appl Immunol. 1983;71(2):117-21. doi: 10.1159/000233373.
By means of double-diffusion precipitation tests in agarose gel with selected infectious mononucleosis (IM) sera, an antigen was detected in sera of patients with syphilis and leprosy. Of 378 syphilis sera tested 39 (10.3%) and of 36 leprosy sera 7 (19.4%) gave positive results. Sera of patients with various other diseases were negative. This antigen was demonstrable in sera of patients with both early and late syphilis and was shown to be unrelated to cardiolipin. Absorption studies of the IM sera with bovine and sheep erythrocytes and guinea pig tissues revealed that this antigen was identical with or closely related to the previously described B antigen of the Paul-Bunnel (P-B) antigenic complex and distinct from heterophile antigens of Hanganutziu-Deicher (H-D) and of Forssman specificity. However, 2 of 89 syphilis sera without the P-B antigen were shown to contain antigen(s) of H-D specificity. None of the syphilis or the leprosy sera contained P-B antibodies, but H-D antibodies were found in 13% of syphilis sera.
通过在琼脂糖凝胶中使用选定的传染性单核细胞增多症（IM）血清进行双向扩散沉淀试验，在梅毒和麻风患者的血清中检测到一种抗原。在检测的378份梅毒血清中，39份（10.3%）呈阳性，在36份麻风血清中，7份（19.4%）呈阳性。患有其他各种疾病的患者血清均为阴性。这种抗原在早期和晚期梅毒患者的血清中均可检测到，并且显示与心磷脂无关。用牛和羊红细胞以及豚鼠组织对IM血清进行吸收研究表明，这种抗原与先前描述的保罗-邦内尔（P-B）抗原复合物的B抗原相同或密切相关，并且与汉加努齐乌-戴歇尔（H-D）嗜异性抗原和福斯曼特异性嗜异性抗原不同。然而，89份不含P-B抗原的梅毒血清中有2份含有H-D特异性抗原。梅毒血清和麻风血清中均未含有P-B抗体，但在13%的梅毒血清中发现了H-D抗体。
