Kano K, Tamura T, Milgrom F
Diagn Immunol. 1984;2(2):105-8.
The BS antigen, the component of the Paul-Bunnell (P-B) antigen complex that is shared by bovine (BRBC) and sheep red blood cells (SRBC), was demonstrated in chloroform-methanol extracts from peripheral blood leukocytes of 4 of 26 healthy young individuals. One of the extracts formed a precipitation line with infectious mononucleosis (IM) sera, which merged into a reaction of identity with the corresponding line formed by the purified P-B antigen of BRBC. The BS antigen of the P-B complex was also demonstrated in tissue sediments of an apparently normal human kidney by means of mixed agglutination test with IM sera and trypsinized BRBC as the indicator. Results of this study suggest that the BS antigen is expressed in normal tissues of some individuals as an intracellular antigen, whereas in various pathologic conditions it is expressed as cell-surface antigen and/or appears in a soluble form in the patient's circulation.
BS抗原是保罗 - 邦内尔（P - B）抗原复合物的组成成分，牛红细胞（BRBC）和绵羊红细胞（SRBC）都含有该抗原。在26名健康年轻个体中，有4人的外周血白细胞氯仿 - 甲醇提取物中检测到了BS抗原。其中一种提取物与传染性单核细胞增多症（IM）血清形成沉淀线，该沉淀线与BRBC纯化P - B抗原形成的相应沉淀线融合成一条同一反应线。通过以IM血清和胰蛋白酶处理的BRBC作为指示剂的混合凝集试验，在一个外观正常的人肾组织沉淀物中也检测到了P - B复合物的BS抗原。本研究结果表明，BS抗原在一些个体的正常组织中作为细胞内抗原表达，而在各种病理情况下，它作为细胞表面抗原表达和/或在患者循环中以可溶性形式出现。
