尸胺在妊娠大鼠体内的体外代谢

In vitro metabolism of cadaverine in the pregnant rat.

作者信息

Henningsson A C, Henningsson S

出版信息

Agents Actions. 1983 Apr;13(2-3):262-4. doi: 10.1007/BF01967348.

DOI:10.1007/BF01967348

Abstract

The in vitro metabolism of 14C-cadaverine by diamine oxidase was investigated in various tissues of pregnant and non-pregnant rats. The metabolites formed were: delta 1-piperideine, delta-aminovaleric acid, carbon dioxide and some unidentified compound(s). In most of the tissues investigated delta 1-piperideine was the predominant metabolite, but considerable amounts of delta-aminovaleric acid and the unidentified compound(s) were also formed. The oxidative products of cadaverine might be of importance in various physiological and pathophysiological connections associated with elevated diamine oxidase levels.

摘要

在怀孕和未怀孕大鼠的各种组织中，研究了二胺氧化酶对14C-尸胺的体外代谢。形成的代谢产物有：δ1-哌啶、δ-氨基戊酸、二氧化碳和一些未鉴定的化合物。在所研究的大多数组织中，δ1-哌啶是主要代谢产物，但也形成了相当数量的δ-氨基戊酸和未鉴定的化合物。尸胺的氧化产物可能在与二胺氧化酶水平升高相关的各种生理和病理生理联系中具有重要意义。